Liu Zhu, Ali Muhammad, Sun Qiannan, Zhang Qi, Wei Chen, Wang Yong, Tang Dong, Li Xin
The Yangzhou Clinical Medical College of Nanjing Medical University, Yangzhou, 225001, China.
Northern Jiangsu People's Hospital, Yangzhou, 225001, China.
Heliyon. 2024 Aug 10;10(16):e36143. doi: 10.1016/j.heliyon.2024.e36143. eCollection 2024 Aug 30.
Technological advances are crucial for the optimization of gastric cancer surgery, and the success of any gastric cancer surgery is based on the correct and precise anatomical determination of the primary tumour and tissue structures. Real-time imaging-guided surgery is showing increasing potential and utility, mainly because it helps to aid intraoperative decision-making. However, intraoperative imaging faces many challenges in the field of gastric cancer. This article summarizes and discusses the following clinical applications of real-time optical imaging and fluorescence-guided surgery for gastric cancer: (1) the potential of quantitative fluorescence imaging in assessing tissue perfusion, (2) vascular navigation and determination of tumour margins, (3) the advantages and limitations of lymph node drainage assessment, and (4) identification of peritoneal metastases. In addition, preclinical study of tumour-targeted fluorescence imaging are discussed.
技术进步对于优化胃癌手术至关重要，任何胃癌手术的成功都基于对原发肿瘤和组织结构的正确且精确的解剖学判定。实时成像引导手术正显示出越来越大的潜力和实用性，主要是因为它有助于辅助术中决策。然而，术中成像在胃癌领域面临诸多挑战。本文总结并讨论了实时光学成像和荧光引导手术在胃癌中的以下临床应用：（1）定量荧光成像在评估组织灌注方面的潜力，（2）血管导航与肿瘤边缘的判定，（3）淋巴结引流评估的优缺点，以及（4）腹膜转移的识别。此外，还讨论了肿瘤靶向荧光成像的临床前研究。
