Phanichphant S, Govithrapong P
Nephron. 1985;40(3):322-8. doi: 10.1159/000183486.
16 peritoneal dialyses were performed in 14 end-stage kidney disease patients; 6 had diabetic nephropathy, and, of the nondiabetic group, 7 had chronic glomerulonephritis, and 1 had polycystic kidney disease. The peritoneal dialysis performed with conventional 1.5% glucose solution, intervened by four consecutive exchanges using 4% hypertonic glucose solution, was compared to 4% mixed hypertonic mannitol solution in the diabetic and nondiabetic group. There was no significant change of serum glucose, when postdialysis with 1.5% glucose solution was compared to 4% mixed hypertonic mannitol solution; however there was a significant change of serum osmolality in both groups. Postdialysis with both 4% hypertonic solutions showed that there was no significant difference of ultrafiltration volume in both groups of patients, but there was a significant difference in serum glucose in the diabetic group. The transport mechanism of mixed hypertonic mannitol solution as compared to hypertonic glucose solution is discussed. The application of hypertonic mannitol solution for clinical use is not advised.
对14例终末期肾病患者进行了16次腹膜透析；其中6例患有糖尿病肾病，在非糖尿病组中，7例患有慢性肾小球肾炎，1例患有多囊肾病。将使用传统1.5%葡萄糖溶液进行的腹膜透析，通过连续四次使用4%高渗葡萄糖溶液进行干预，与糖尿病组和非糖尿病组中的4%混合高渗甘露醇溶液进行比较。当将使用1.5%葡萄糖溶液透析后的血清葡萄糖与4%混合高渗甘露醇溶液透析后的血清葡萄糖进行比较时，血清葡萄糖没有显著变化；然而，两组的血清渗透压均有显著变化。使用两种4%高渗溶液透析后显示，两组患者的超滤量没有显著差异，但糖尿病组的血清葡萄糖有显著差异。讨论了混合高渗甘露醇溶液与高渗葡萄糖溶液相比的转运机制。不建议将高渗甘露醇溶液用于临床。
