Twist1在细胞分化中的新兴生物学功能。

Emerging biological functions of Twist1 in cell differentiation.

作者信息

Tu Mengjie, Ge Bingqian, Li Jiali, Pan Yanbing, Zhao Binbin, Han Jiayang, Wu Jialin, Zhang Kaifeng, Liu Guangchao, Hou Mengwen, Yue Man, Han Xu, Sun Tiantian, An Yang

机构信息

Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Henan University, Kaifeng, China.

Henan Provincial Engineering Center for Tumor Molecular Medicine, Kaifeng Key Laboratory of Cell Signal Transduction, Henan University, Kaifeng, China.

出版信息

Dev Dyn. 2025 Jan;254(1):8-25. doi: 10.1002/dvdy.736. Epub 2024 Sep 10.

DOI:10.1002/dvdy.736

PMID:39254141

Abstract

Twist1 is required for embryonic development and expresses after birth in mesenchymal stem cells derived from mesoderm, where it governs mesenchymal cell development. As a well-known regulator of epithelial-mesenchymal transition or embryonic organogenesis, Twist1 is important in a variety of developmental systems, including mesoderm formation, neurogenesis, myogenesis, cranial neural crest cell migration, and differentiation. In this review, we first highlight the physiological significance of Twist1 in cell differentiation, including osteogenic, chondrogenic, and myogenic differentiation, and then detail its probable molecular processes and signaling pathways. On this premise, we summarize the significance of Twist1 in distinct developmental disorders and diseases to provide a reference for studies on cell differentiation/development-related diseases.

摘要

Twist1是胚胎发育所必需的，出生后在源自中胚层的间充质干细胞中表达，在那里它控制间充质细胞的发育。作为上皮-间充质转化或胚胎器官发生的著名调节因子，Twist1在多种发育系统中都很重要，包括中胚层形成、神经发生、肌发生、颅神经嵴细胞迁移和分化。在本综述中，我们首先强调Twist1在细胞分化（包括成骨、软骨生成和肌生成分化）中的生理意义，然后详细阐述其可能的分子过程和信号通路。在此前提下，我们总结Twist1在不同发育障碍和疾病中的意义，为细胞分化/发育相关疾病的研究提供参考。