Nutritional therapy in advanced cancer. Setting realistic goals.

Cancer cachexia is a complex syndrome resulting from metabolic disturbances, mechanical obstacles, and behavioral alterations. Assessments of the potential benefits of nutritional support for an individual patient must reflect the cancer stage and prognosis, the patient's expressed wishes, and the impact of treatment on the family unit. Enteral or parenteral alimentation may preserve body mass during aggressive, potentially curative therapy of early cancer. Palliation may be provided for the more advanced patient whose major problem is not being able to eat. In terminal illness, feeding may no longer be therapeutic--it may briefly prolong life with considerable morbidity and expense. At each stage, decisions should be based on realistic assessments of possible gains and losses to the patient's life and overall well-being.