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单次接触可卡因产生的旋转行为敏化。

Sensitization of rotational behavior produced by a single exposure to cocaine.

作者信息

Guan L C, Robinson T E, Becker J B

出版信息

Pharmacol Biochem Behav. 1985 May;22(5):901-3. doi: 10.1016/0091-3057(85)90545-3.

DOI:10.1016/0091-3057(85)90545-3
PMID:3925466
Abstract

In rats with a unilateral 6-OHDA lesion of the substantia nigra a single exposure to cocaine significantly enhanced the ipsiversive rotational behavior produced by a second injection given one week later. It is concluded that it is not necessary to repeatedly administer psychomotor stimulant drugs to produce long-lasting changes in brain and behavior.

摘要

在患有单侧黑质6-羟基多巴胺损伤的大鼠中，单次接触可卡因显著增强了一周后第二次注射所产生的向患侧旋转行为。得出的结论是，没有必要反复给予精神运动性兴奋药物来在大脑和行为上产生持久变化。

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