George F R, Ritz M C, Collins A C
Psychopharmacology (Berl). 1985;85(2):151-3. doi: 10.1007/BF00428405.
Pretreatment with prostaglandin synthetase inhibitors (PGSI) significantly decreases the CNS effects of ethanol across the entire ethanol dose-response curve. PGSIs do not significantly affect ethanol metabolism. These effects have been shown in HS/Ibg, LS/Ibg, and SS/Ibg males and females. These strains of mice are useful in alcohol research but are not widely available. The present study examined the possibility of similar effects in C57BL/6 and C3H/2 mice of both sexes. PGSI pretreatment significantly reduced ethanol sleep time across both sexes and genotypes in a dose-dependent manner. Females of both strains required more PGSI to antagonize ethanol's actions relative to males. Within sex, mice with greater sensitivity to ethanol required more PGSI to optimally reduce sleep time than less sensitive mice. These results extend previous findings, and support our hypothesis that one of ethanol's primary mechanisms of action in the CNS is to increase the synthesis of prostaglandins.
用前列腺素合成酶抑制剂（PGSI）进行预处理，在整个乙醇剂量反应曲线上，能显著降低乙醇对中枢神经系统的作用。PGSI对乙醇代谢无显著影响。这些作用在HS/Ibg、LS/Ibg和SS/Ibg品系的雄性和雌性小鼠中均已得到证实。这些小鼠品系在酒精研究中很有用，但并不广泛可得。本研究检验了在C57BL/6和C3H/2品系的雌雄小鼠中出现类似作用的可能性。PGSI预处理以剂量依赖的方式显著缩短了雌雄两性及不同基因型小鼠的乙醇睡眠时间。相对于雄性，两个品系的雌性小鼠需要更多的PGSI来拮抗乙醇的作用。在同一性别内，对乙醇敏感性较高的小鼠比敏感性较低的小鼠需要更多的PGSI才能最佳地缩短睡眠时间。这些结果扩展了先前的发现，并支持了我们的假设，即乙醇在中枢神经系统中的主要作用机制之一是增加前列腺素的合成。
