George F R, Jackson S J, Collins A C
Psychopharmacology (Berl). 1981;74(3):241-4. doi: 10.1007/BF00427102.
Previous studies in our laboratory have demonstrated that inhibition of prostaglandin biosynthesis through pretreatment with aspirin and other prostaglandin synthetase inhibitors (PGSI) significantly reduces CNS sensitivity to a hypnotic dose of ethanol. Indomethacin, a potent PGSI, was administered to male LS, SS, and HS/Ibg mice (65 +/- 10 days of age) 15 min prior to administration of a hypnotic dose of ethanol or pentobarbital. Doses of indomethacin used were identical to those previously reported as optimally antagonizing ethanol-induced sleep. Another group received a vehicle-control injection, while a third group also received a control injection, but were placed in a incubator maintained at 30 +/ 1 degrees C. Body temperatures were recorded periodically for several hours. Both indomethacin and incubation significantly reduced hypothermia induced by ethanol and pentobarbital. Incubation increased sleep time after ethanol, but did not affect pentobarbital sleep time. These results suggest that the hypnotic and hypothermic effects of ethanol, although possibly mediated through prostaglandins, apparently are not causally linked.
我们实验室之前的研究表明，通过用阿司匹林和其他前列腺素合成酶抑制剂（PGSI）进行预处理来抑制前列腺素生物合成，可显著降低中枢神经系统对催眠剂量乙醇的敏感性。在给予催眠剂量的乙醇或戊巴比妥前15分钟，给雄性LS、SS和HS/Ibg小鼠（65±10日龄）注射强效PGSI吲哚美辛。所用吲哚美辛的剂量与先前报道的最佳拮抗乙醇诱导睡眠的剂量相同。另一组接受载体对照注射，而第三组也接受对照注射，但被置于温度保持在30±1℃的培养箱中。定期记录体温数小时。吲哚美辛和培养均显著降低了乙醇和戊巴比妥诱导的体温过低。培养增加了乙醇后的睡眠时间，但不影响戊巴比妥的睡眠时间。这些结果表明，乙醇的催眠和体温过低作用，尽管可能通过前列腺素介导，但显然没有因果联系。
