Milan Unit, Institute of Genetic and Biomedical Research, National Research Council, Milan, Italy.
Istituto di Ricovero e Cura a Carattere Scientifico Humanitas Research Hospital, Milan, Italy.
Physiology (Bethesda). 2025 Jan 1;40(1):0. doi: 10.1152/physiol.00031.2024. Epub 2024 Sep 10.
RANKL and its cognate receptor RANK are crucial regulators of bone metabolism in physiological as well as in pathological conditions. Here we go through the works that unveiled the paramount role of this signaling pathway. We focus on the RANKL cytokine, whose alterations are responsible for rare and common bone diseases. We describe recent insights on the regulation of RANKL expression, which provide new hints for the pharmacological regulation of this molecule. Based on the multiple functions exerted by RANKL (within and outside the bone tissue), we advise caution regarding the potential unintended consequences of its inhibition.
RANKL 和其同源受体 RANK 是生理和病理条件下骨代谢的关键调节因子。本文通过阐述该信号通路的主要作用，对相关研究进行了综述。我们重点介绍了 RANKL 细胞因子，其改变可导致罕见和常见的骨骼疾病。我们描述了 RANKL 表达调控的最新研究进展，为该分子的药理学调控提供了新的线索。鉴于 RANKL（在骨骼组织内外）发挥的多种功能，我们建议在抑制 RANKL 时要谨慎，以防出现意料之外的后果。
