Abdul-Azees Parveez Ahamed, Rajesh Rahul, Block Travis J, Dean David D, Yeh Chih-Ko, Capitano Maegan, Kacena Melissa, Chen Xiao-Dong, Marinković Miloš
Department of Comprehensive Dentistry, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229 - 3900, USA.
Arkansas College of Osteopathic Medicine, Fort Smith, AR, 72916, USA.
Curr Osteoporos Rep. 2025 May 23;23(1):23. doi: 10.1007/s11914-025-00915-4.
This review explores the role of cell communication network (CCN) proteins in regulating skeletal physiology, aging, and disease, particularly within the context of balanced bone remodeling.
Recent conceptualization of paracrine and endocrine networks in bone marrow as a form of osteoimmunological crosstalk suggests a significant role for matricellular signaling in regulating bone homeostasis. As multifunctional adapters of cell-matrix interactions, CCNs are emerging as a focal point for parathyroid hormone (PTH) signaling and regulation of the RANKL/RANK/OPG axis in skeletal aging. Altered bone marrow CCN expression creates a permissive environment for accelerated postmenopausal bone loss and may contribute to the pathogenesis of osteoporosis and other diseases related to skeletal aging. CCNs modulate fundamental signaling mechanisms in bone development, homeostasis and repair. During aging, dysregulation of CCNs may negatively affect skeletal health and contribute to disease progression. As a result, CCNs may constitute promising therapeutic targets for improving and maintaining aging bone health.
本综述探讨细胞通讯网络（CCN）蛋白在调节骨骼生理、衰老和疾病中的作用，特别是在平衡骨重塑的背景下。
骨髓中旁分泌和内分泌网络作为骨免疫学串扰的一种形式，其最近的概念化表明基质细胞信号在调节骨稳态中具有重要作用。作为细胞-基质相互作用的多功能衔接分子，CCN蛋白正在成为甲状旁腺激素（PTH）信号传导以及骨骼衰老过程中RANKL/RANK/OPG轴调节的焦点。骨髓CCN表达的改变为绝经后骨质流失加速创造了有利环境，并可能导致骨质疏松症和其他与骨骼衰老相关疾病的发病机制。CCN蛋白调节骨发育、稳态和修复中的基本信号机制。在衰老过程中，CCN蛋白的失调可能会对骨骼健康产生负面影响，并促进疾病进展。因此，CCN蛋白可能构成改善和维持衰老骨骼健康的有前景的治疗靶点。
