Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.
Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.
Pancreatology. 2024 Nov;24(7):1031-1039. doi: 10.1016/j.pan.2024.09.002. Epub 2024 Sep 5.
The incidence of pancreatic cancer is on the rise, and its prognosis remains poor. Recent reports have established a link between the gut and oral microbiome and pancreatic cancer. However, the intricacies of this association within the Japanese population remain unclear. In this study, we investigated the gut and oral microbiomes of Japanese patients with pancreatic cancer, comparing them with those of healthy individuals.
We recruited 30 patients with untreated pancreatic cancer and 18 healthy controls at Kyoto University Hospital (2018-2022). We performed a comprehensive 16S rRNA gene sequencing to analyze their gut and oral microbiomes.
Analysis revealed that the diversity of the gut and oral microbiomes of patients with pancreatic cancer was reduced compared to that of the healthy controls. Specifically, we observed an increase in the genus Streptococcus in both the gut and oral microbiomes and a significant decrease in several butyrate-producing bacteria in fecal samples. Moreover, bacteria such as Streptococcus mitis and Holdemanella biformis were present in pancreatic cancer tissues, suggesting that they might influence the carcinogenesis and progression of pancreatic cancer.
The gut and oral microbiome differed between patients with pancreatic cancer and healthy controls, with a notable decrease in butyrate-producing bacteria in the gut microbiome of the patients. This suggests that there may be a distinct microbial signature associated with pancreatic cancer in the Japanese population. Further studies are required to elucidate the microbiome's causal role in this cancer and help develop prognostic markers or targeted therapies.
胰腺癌的发病率呈上升趋势，其预后仍然较差。最近的报告已经确定了肠道和口腔微生物组与胰腺癌之间的联系。然而，这种关联在日本人群中的复杂性尚不清楚。在这项研究中，我们研究了日本胰腺癌患者的肠道和口腔微生物组，并将其与健康个体进行了比较。
我们招募了京都大学医院（2018-2022 年）的 30 名未经治疗的胰腺癌患者和 18 名健康对照者。我们进行了全面的 16S rRNA 基因测序，以分析他们的肠道和口腔微生物组。
分析表明，与健康对照组相比，胰腺癌患者的肠道和口腔微生物组多样性降低。具体而言，我们观察到肠道和口腔微生物组中链球菌属的增加，以及粪便样本中几种产生丁酸的细菌的显著减少。此外，链球菌和双歧杆菌等细菌存在于胰腺癌组织中，表明它们可能影响胰腺癌的发生和发展。
胰腺癌患者的肠道和口腔微生物组与健康对照组不同，患者肠道微生物组中产生丁酸的细菌明显减少。这表明在日本人群中，可能存在与胰腺癌相关的独特微生物特征。需要进一步的研究来阐明微生物组在这种癌症中的因果作用，并帮助开发预后标志物或靶向治疗。
