Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, USA.
Obesity, Lifestyle, and Genetic Adaptations Study Group, Pago Pago, Samoa.
Obesity (Silver Spring). 2024 Oct;32(10):1833-1843. doi: 10.1002/oby.24102. Epub 2024 Sep 10.
The objective of this study was to determine the preliminary effectiveness of an intervention to mitigate adverse pregnancy outcomes associated with pre-pregnancy obesity in American Samoa.
We enrolled n = 80 low-risk pregnant women at <14 weeks' gestation. A complete case analysis was conducted with randomized group assignment (group prenatal care-delivered intervention vs. one-on-one usual care) as the independent variable. Primary outcomes were gestational weight gain and postpartum weight change. Secondary outcomes included gestational diabetes screening and exclusive breastfeeding at 6 weeks post partum. Other outcomes reported include gestational diabetes incidence, preterm birth, mode of birth, infant birth weight, and macrosomia.
Gestational weight gain was lower among group versus usual care participants (mean [SD], 9.46 [7.24] kg vs. 14.40 [8.23] kg; p = 0.10); postpartum weight change did not differ between groups. Although the proportion of women who received adequate gestational diabetes screening (78.4% group; 65.6% usual care) was similar, there were clinically important between-group differences in exclusive breastfeeding (44.4% group; 25% usual care), incidence of gestational diabetes (27.3% group; 40.0% usual care), and macrosomia (8.3% group; 29.0% usual care).
It may be possible to address multiple risk factors related to intergenerational transmission of obesity in this high-risk setting using a group care-delivered intervention.
本研究旨在确定一项干预措施在减少美属萨摩亚与孕前肥胖相关的不良妊娠结局方面的初步效果。
我们在<14 周妊娠时纳入了 80 名低危孕妇。采用完全病例分析,以随机分组(小组产前护理干预组与一对一常规护理组)为自变量。主要结局是妊娠体重增加和产后体重变化。次要结局包括妊娠期糖尿病筛查和产后 6 周纯母乳喂养。报告的其他结局包括妊娠期糖尿病发病率、早产、分娩方式、婴儿出生体重和巨大儿。
与常规护理组相比,小组护理组的妊娠体重增加量较低(平均[标准差],9.46[7.24]kg 比 14.40[8.23]kg;p=0.10);两组产后体重变化无差异。尽管接受充分妊娠期糖尿病筛查的女性比例(小组组 78.4%;常规护理组 65.6%)相似,但在纯母乳喂养(小组组 44.4%;常规护理组 25%)、妊娠期糖尿病发病率(小组组 27.3%;常规护理组 40.0%)和巨大儿(小组组 8.3%;常规护理组 29.0%)方面存在显著的组间差异。
在这种高风险环境中,使用小组护理干预可能可以解决与肥胖代际传递相关的多个风险因素。