白细胞介素在胰腺癌中的作用：文献综述

Role of Interleukins in Pancreatic Cancer: A Literature Review.

作者信息

Rafaqat Saira, Khurshid Huma, Hafeez Ramsha, Arif Mehnaz, Zafar Ayesha, Gilani Mahrukh, Ashraf Habiba, Rafaqat Sana

机构信息

Department of Zoology, Lahore College for Women University, Lahore, 54000, Pakistan.

Department of Biotechnology (Human Genetics), Lahore College for Women University, Lahore, 54000, Pakistan.

出版信息

J Gastrointest Cancer. 2024 Dec;55(4):1498-1510. doi: 10.1007/s12029-024-01111-w. Epub 2024 Sep 11.

DOI:10.1007/s12029-024-01111-w

PMID:39256264

Abstract

PURPOSE

This review article summarizes the pathophysiological aspects of interleukins (ILs) including IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, and IL-10 in pancreatic cancer (PC).

METHODS

Science Direct, PubMed, and Google Scholar were used for the literature review. The search was conducted until August 12, 2024, and particular keywords such as "Pancreatic Cancer," "Interleukins," "Pathophysiological Aspects," "Immunosuppression," "Invasiveness," and "Metastasis" were used. Focusing on interleukins related to pancreatic cancer, 61 original studies were included: 32 studies for human patients, 16 studies for animal models, and 13 studies for both animal models and human patients. All types of PC were considered. The timeframe of 1991 to 2024 was chosen for clinical studies.

RESULTS

In epithelial pancreatic tumors, IL-1 is a major inflammation factor. Serum concentrations of soluble interleukin-2-receptor were considerably greater in patients with PC and chronic pancreatitis than in healthy individuals. In comparison to controls, pancreatic cancer patients had considerably greater levels of macrophage colony-stimulating factor and significantly lower levels of stem cell factor and IL-3. The tissues and cells of pancreatic cancer have higher concentrations of IL-4 receptors. IL-5 has a role in the accumulation of pancreatic fibrosis. For individuals with pancreatic ductal adenocarcinoma (PDAC), a high serum level of IL-6 may be a separate risk factor for the development of widespread liver metastases. PDAC patients' peripheral blood mononuclear cells exhibit a substantial upregulation of IL-7 receptor. The role of IL-8 in the growth and spread of PC in humans. The miR-200a/β-catenin axis may be the mechanism by which IL-9 stimulates the proliferation and metastasis of PC cells. Blocking IL-10 in the local microenvironment appears to result in a significant reversal of tumor-induced immunosuppression.

CONCLUSION

The article concludes that interleukins 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10 played significant roles in the pathogenesis of PC.

摘要

目的

这篇综述文章总结了白细胞介素（IL）包括IL-1、IL-2、IL-3、IL-4、IL-5、IL-6、IL-7、IL-8、IL-9和IL-10在胰腺癌（PC）中的病理生理学方面。

方法

使用科学Direct、PubMed和谷歌学术进行文献综述。搜索持续到2024年8月12日，并使用了“胰腺癌”“白细胞介素”“病理生理学方面”“免疫抑制”“侵袭性”和“转移”等特定关键词。聚焦于与胰腺癌相关的白细胞介素，纳入了61项原始研究：32项针对人类患者的研究，16项针对动物模型的研究，以及13项针对动物模型和人类患者的研究。考虑了所有类型的胰腺癌。临床研究选择了1991年至2024年的时间范围。

结果

在上皮性胰腺肿瘤中，IL-1是主要的炎症因子。胰腺癌和慢性胰腺炎患者血清中可溶性白细胞介素-2受体的浓度明显高于健康个体。与对照组相比，胰腺癌患者巨噬细胞集落刺激因子水平明显更高，而干细胞因子和IL-3水平明显更低。胰腺癌的组织和细胞中IL-4受体浓度更高。IL-5在胰腺纤维化的积累中起作用。对于胰腺导管腺癌（PDAC）患者，血清高水平的IL-6可能是发生广泛肝转移的一个独立危险因素。PDAC患者外周血单个核细胞中IL-7受体显著上调。IL-8在人类胰腺癌生长和扩散中的作用。miR-200a/β-连环蛋白轴可能是IL-�刺激胰腺癌细胞增殖和转移的机制。在局部微环境中阻断IL-10似乎会导致肿瘤诱导的免疫抑制显著逆转。