Department of Evidence-Based Medicine, Southwest Medical University, Luzhou, Sichuan, China.
Preventive Health Center, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Expert Opin Ther Targets. 2024 Sep;28(9):789-806. doi: 10.1080/14728222.2024.2401518. Epub 2024 Sep 10.
Nrf2 regulates mild stress, chronic inflammation, and metabolic changes by regulating different immune cells via downstream signaling. Collection of information about the role of Nrf2 in inflammatory autoimmune diseases will better understand the therapeutic potential of targeting Nrf2 in these diseases.
In this review, we comprehensively discussed biological function of Nrf2 in different immune cells, including Nrf2 preventing oxidative tissue injury, affecting apoptosis of immune cells and inflammatory cytokine production. Moreover, we discussed the role of Nrf2 in the development of inflammatory autoimmune diseases.
Nrf2 binds to downstream signaling molecules and then provides durable protection against different cellular and organ stress. It has emerged as an important target for inflammatory autoimmune diseases. Development of Nrf2 modulator drugs needs to consider factors such as target specificity, short/long term safety, disease indication identification, and the extent of variation in Nrf2 activity. We carefully discussed the dual role of Nrf2 in some diseases, which helps to better target Nrf2 in the future.
Nrf2 通过调节下游信号通路来调节不同的免疫细胞，从而调节轻度应激、慢性炎症和代谢变化。收集关于 Nrf2 在炎症性自身免疫疾病中的作用的信息将有助于更好地了解在这些疾病中靶向 Nrf2 的治疗潜力。
在这篇综述中，我们全面讨论了 Nrf2 在不同免疫细胞中的生物学功能，包括 Nrf2 预防氧化组织损伤、影响免疫细胞凋亡和炎症细胞因子产生。此外，我们还讨论了 Nrf2 在炎症性自身免疫疾病发展中的作用。
Nrf2 与下游信号分子结合，然后为不同的细胞和器官应激提供持久的保护。它已成为炎症性自身免疫疾病的一个重要靶点。开发 Nrf2 调节剂药物需要考虑目标特异性、短期/长期安全性、疾病指征识别以及 Nrf2 活性变化的程度等因素。我们仔细讨论了 Nrf2 在某些疾病中的双重作用，这有助于我们更好地在未来靶向 Nrf2。
