Larsen J K, Bjørum N, Kirkegaard C, Aggernaes H, Krog-Meyer I, Lund-Laursen A M, Mikkelsen P L
Acta Psychiatr Scand. 1985 May;71(5):499-505. doi: 10.1111/j.1600-0447.1985.tb05063.x.
The dexamethasone suppression test (DST), the thyrotropin releasing hormone (TRH) test and the Newcastle II depression rating (NII) were compared with the clinical diagnosis and evaluated in 61 patients fulfilling the criteria of an affective disorder according to the DSM-III classification. A statistically significant correlation between clinical diagnosis and DST as well as NII, but not between clinical diagnosis and TRH test, was found. There was no correlation between DST and the severity of depression according to the Hamilton depression rating. The nosographic and the diagnostic specificities and sensitivities for the DST, TRH test and NII and DST and NII, a nosographic sensitivity of 50% and a nosographic specificity of 84% were found. Correspondingly, the diagnostic sensitivity was 43% and the diagnostic specificity was 88%. The DST and the TRH test were found of no value in the prediction of the response to antidepressive treatment. Mainly because of a low diagnostic sensitivity the NII, the DST and the TRH test are of limited value in the diagnosis of depressive disorders.
对61例符合DSM-III分类中情感障碍标准的患者，将地塞米松抑制试验（DST）、促甲状腺激素释放激素（TRH）试验和纽卡斯尔II抑郁评定量表（NII）与临床诊断进行比较并评估。发现临床诊断与DST以及NII之间存在统计学显著相关性，但临床诊断与TRH试验之间不存在相关性。根据汉密尔顿抑郁评定量表，DST与抑郁严重程度之间无相关性。发现DST、TRH试验和NII以及DST和NII的疾病分类特异性和敏感性，疾病分类敏感性为50%，疾病分类特异性为84%。相应地，诊断敏感性为43%，诊断特异性为88%。发现DST和TRH试验在预测抗抑郁治疗反应方面无价值。主要由于诊断敏感性低，NII、DST和TRH试验在抑郁症诊断中的价值有限。
