Aggernaes H, Kirkegaard C, Krog-Meyer I, Kijne B, Larsen J K, Laursen A L, Lykke-Olesen L, Mikkelsen P L, Rasmussen S, Bjørum N
Acta Psychiatr Scand. 1983 Apr;67(4):258-64. doi: 10.1111/j.1600-0447.1983.tb06739.x.
Dexamethasone suppression test (DST) and thyrotropin releasing hormone (TRH) stimulation test were performed in 34 patients with endogenous depression. Compared with 33 psychiatric controls (limit of discrimination for serum cortisol of 275 nmol/l = 10 micrograms/100 ml) the specificity of the DST was 91% and the sensitivity was 65%. Compared with 24 healthy subjects the sensitivity of the TRH test was 24%, and the combined sensitivity for the DST and the TRH test was 76%. In contrast to the TRH test the DST showed a significant relationship (r = 0.54, P less than 0.01) to the Hamilton Rating Score. Repeating the tests after clinical recovery parallel changes of the two tests were found in 14 of 19 patients with abnormal DST in the depressed phase. In the remaining five patients the DST normalized, while the TRH test remained unchanged. It is suggested that both the apparent higher diagnostic sensitivity and the higher rate of normalization after clinical recovery of the DST is due to the dependency of the severity of depression.
对34例内源性抑郁症患者进行了地塞米松抑制试验（DST）和促甲状腺激素释放激素（TRH）刺激试验。与33名精神科对照者（血清皮质醇的鉴别阈值为275 nmol/l = 10微克/100毫升）相比，DST的特异性为91%，敏感性为65%。与24名健康受试者相比，TRH试验的敏感性为24%，DST和TRH试验的联合敏感性为76%。与TRH试验不同，DST与汉密尔顿评定量表评分呈显著相关性（r = 0.54，P<0.01）。在抑郁期DST异常的19例患者中，有14例在临床康复后重复试验时发现两项试验有平行变化。在其余5例患者中，DST恢复正常，而TRH试验保持不变。提示DST明显较高的诊断敏感性以及临床康复后较高的恢复正常率是由于抑郁症严重程度的依赖性所致。
