印度人群中下颌前突与 Matrilin-1、骨形态发生蛋白、Tyr67Asn、同源盒蛋白 hox-A2、Rho-GTP 酶激活蛋白和 基因之间的关系。
Association between mandibular prognathism and Matrilin-1, bone morphogenic protein, Tyr67Asn, homeobox protein hox-A2, Rho-GTPase activating protein, and genes in the Indian population.
机构信息
Symbiosis International (Deemed University), Pune, India.
Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, Pune, India.
出版信息
Folia Med (Plovdiv). 2024 Aug 31;66(4):528-535. doi: 10.3897/folmed.66.e129047.
Mandibular prognathism (MP) patients present with aesthetic concerns and functional issues, including difficulties in mastication and pronunciation. Studies revealed that mandibular prognathism had definitive Mendelian inheritance patterns. This study aimed to ascertain distinct genetic markers associated with mandibular prognathism in individuals of Indian descent, focusing on exploring the prevalent genetic variations associated with certain genes. This study sought to identify the association of the following gene markers with mandibular prognathism: 1) Matrilin-1 (MATN1) (rs1065755), 2) Bone morphogenic protein 3 (BMP-3) (Tyr67Asn), 3) Homeobox protein hox-A2 (HOXA2) (Val327Ile), 4) Rho-GTPase activating protein (ARHGAP 21) (Gly1121Ser), 5) Myosin 1H (MYO1H) (rs10850110).
下颌前突（MP）患者存在美观和功能问题，包括咀嚼和发音困难。研究表明，下颌前突具有明确的孟德尔遗传模式。本研究旨在确定与印度裔个体下颌前突相关的独特遗传标记物，重点研究与某些基因相关的常见遗传变异。本研究旨在确定以下基因标记物与下颌前突的关联：1）软骨中间层素 1（MATN1）（rs1065755），2）骨形态发生蛋白 3（BMP-3）（Tyr67Asn），3）同源盒蛋白 hox-A2（HOXA2）（Val327Ile），4）Rho-GTP 酶激活蛋白（ARHGAP21）（Gly1121Ser），5）肌球蛋白 1H（MYO1H）（rs10850110）。
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