Wang Rui, Wu Ni-Sha, Wang Li, Zhang Zhi-Zhao, Wang Cheng-Fang, Wang Yan, Liang Yan, Zhang Yi, Qi Xiao-Wei
Department of Breast and Thyroid Surgery, Southwest Hospital Army Medical University Chongqing China.
Department of Infection China Academy of Chinese Medical Sciences, Guang'anmen Hospital Beijing China.
Cancer Innov. 2024 Sep 9;3(5):e139. doi: 10.1002/cai2.139. eCollection 2024 Oct.
Previous studies have highlighted the crucial role of in the development of various cancers, including breast, pancreatic, and gastric cancers. However, research into the involvement of is often confined to specific tumor types, with a noticeable lack of comprehensive studies spanning multiple cancer forms. The potential of as a diagnostic or prognostic cancer biomarker has not been fully explored.
In this study, we combined bioinformatics and immunohistochemistry analyses to examine the expression patterns and functions of in cancerous and adjacent noncancerous tissues across a range of tumors.
Our data indicate that may serve as a novel prognostic biomarker and therapeutic target in certain cancers.
We found significant upregulation of expression levels in the majority of cancer cases examined. Furthermore, can influence cancer prognosis by modulating the tumor microenvironment, immune cell infiltration, and tumor stemness, among other factors. Additionally, we examined the associations between anticancer drug sensitivity and expression, which could aid in the development of more precise clinical therapies.
先前的研究强调了[具体内容未给出]在包括乳腺癌、胰腺癌和胃癌等多种癌症发展中的关键作用。然而，对[具体内容未给出]参与情况的研究往往局限于特定肿瘤类型，明显缺乏涵盖多种癌症形式的全面研究。[具体内容未给出]作为癌症诊断或预后生物标志物的潜力尚未得到充分探索。
在本研究中，我们结合生物信息学和免疫组织化学分析，以检查[具体内容未给出]在一系列肿瘤的癌组织和相邻非癌组织中的表达模式和功能。
我们的数据表明，[具体内容未给出]可能在某些癌症中作为一种新的预后生物标志物和治疗靶点。
我们发现在大多数所检查的癌症病例中，[具体内容未给出]表达水平显著上调。此外，[具体内容未给出]可通过调节肿瘤微环境、免疫细胞浸润和肿瘤干性等因素影响癌症预后。此外，我们研究了抗癌药物敏感性与[具体内容未给出]表达之间的关联，这有助于开发更精确的临床治疗方法。
