miR-640的作用：乳腺癌Wnt7b/β-连环蛋白信号通路中的潜在抑制因子

The Role of miR-640: A Potential Suppressor in Breast Cancer Wnt7b/β-catenin Signaling Pathway.

作者信息

Tang Chun, Wang Xuehui, Ji Changle, Zheng Wenfang, Yu Yunhe, Deng Xiaochong, Zhou Xiqian, Fang Lin

机构信息

Clinical Medical College of Shanghai Tenth People's Hospital, Nanjing Medical University, Nanjing, China.

Department of Thyroid and Breast Surgery, Taizhou Fourth People's Hospital, Taizhou, China.

出版信息

Front Oncol. 2021 Apr 12;11:645682. doi: 10.3389/fonc.2021.645682. eCollection 2021.

In this study, we demonstrated that miR-640 is significantly downregulated in breast cancer (BC) tissues and cell lines. Overexpression of miR-640 inhibited the proliferation and migration of BC and , while depletion of miR-640 exhibited the opposite effect. Importantly, miR-640 could directly target Wnt7b, thereby regulating Wnt/β-catenin signaling pathway in BC. In conclusion, miR-640/Wnt7b suppresses BC cells tumorigenesis Wnt/β-catenin signaling pathway, which might be novel targets for BC targeted therapy.