Radosevich J K, Scott G H, Olson G B
Am J Vet Res. 1985 Apr;46(4):875-8.
Transfer factor-type substances obtained from leukocytic cells and fluid portions of bovine colostrum caused effective passive transfer of delayed-type hypersensitivity responses across species barriers. Passive transfer of Brucella abortus sensitivity was obtained with equal regularity when using components derived from peripheral blood and colostrum of dams sensitized at 3 and 9 months of age. Colostral feedings to calves caused the passive transfer of delayed-type hypersensitivity as early as 2 days after parturition. The findings indicated that colostral components were important in the process of cell-mediated immunity.
从白细胞和牛初乳的液体部分获得的转移因子样物质能有效地跨物种屏障被动转移迟发型超敏反应。当使用来自3个月和9个月大时致敏母羊的外周血和初乳中的成分时，能同样规律地实现布鲁氏菌流产敏感性的被动转移。给犊牛喂食初乳最早在分娩后2天就能引起迟发型超敏反应的被动转移。这些发现表明初乳成分在细胞介导免疫过程中很重要。
