Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
College of Chemistry, University of Chinese Academy of Sciences, Beijing 100049, China.
Chem Commun (Camb). 2024 Sep 26;60(78):10938-10941. doi: 10.1039/d4cc03146f.
Here, we present a biosynthesized material M1 for immune checkpoint blocking therapy. M1 could realize a morphological transformation from globular to fibrous in the presence of cathepsin B (CtsB) after entering tumor cells. The GO203 peptides of M1 are exposed, which could bind to mucin 1 (MUC1) to suppress the homodimerization process of MUC1, thereby downregulating PD-L1 expression.
在这里，我们提出了一种用于免疫检查点阻断治疗的生物合成材料 M1。M1 在进入肿瘤细胞后，在组织蛋白酶 B (CtsB) 的存在下，能够实现从球形到纤维状的形态转变。M1 的 GO203 肽被暴露出来，能够与粘蛋白 1 (MUC1) 结合，抑制 MUC1 的同源二聚化过程，从而下调 PD-L1 的表达。
