Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, 310000, P. R. China.
Zhejiang Key Laboratory of Plastic Modification and Processing Technology, College of Materials Science & Engineering, Zhejiang University of Technology, Hangzhou, 310014, P. R. China.
Adv Sci (Weinh). 2024 Nov;11(42):e2406287. doi: 10.1002/advs.202406287. Epub 2024 Sep 11.
Coordinating the immune response and bioenergy metabolism in bone defect environments is essential for promoting bone regeneration. Mitochondria are important organelles that control internal balance and metabolism. Repairing dysfunctional mitochondria has been proposed as a therapeutic approach for disease intervention. Here, an engineered hierarchical hydrogel with immune responsiveness can adapt to the bone regeneration environment and mediate the targeted mitochondria transfer between cells. The continuous supply of mitochondria by macrophages can restore the mitochondrial bioenergy of bone marrow mesenchymal stem cells (BMSC). Fundamentally solving the problem of insufficient energy support of BMSCs caused by local inflammation during bone repair and regeneration. This discovery provides a new therapeutic strategy for promoting bone regeneration and repair, which has research value and practical application prospects in the treatment of various diseases caused by mitochondrial dysfunction.
协调骨缺损环境中的免疫反应和生物能量代谢对于促进骨再生至关重要。线粒体是控制内部平衡和代谢的重要细胞器。修复功能失调的线粒体已被提议作为一种疾病干预的治疗方法。在这里，一种具有免疫响应性的工程化分级水凝胶可以适应骨再生环境，并介导细胞间靶向线粒体转移。巨噬细胞持续供应线粒体可以恢复骨髓间充质干细胞（BMSC）的线粒体生物能量。从根本上解决了骨修复和再生过程中局部炎症导致的 BMSC 能量供应不足的问题。这一发现为促进骨再生和修复提供了一种新的治疗策略，对于治疗各种由线粒体功能障碍引起的疾病具有研究价值和实际应用前景。
