Tunér K, Nord C E
Ann Otol Rhinol Laryngol. 1985 May-Jun;94(3):278-80.
A total of 75 patients with recurrent tonsillitis, between 15 and 44 years of age, were divided into three groups, two of which were treated with antibiotics before surgery. Bacteriological specimens were collected before treatment started and the microflora of the excised tonsils were analyzed. Bacteroides species were found in the tonsils of 83% of the patients, and 50% of these microorganisms were beta-lactamase producers. Other bacteria found were Staphylococcus aureus in 45%, beta-streptococci group A in 4%, and beta-streptococci groups C and G in 24%. Hemophilus species were isolated from 50%, but no strains produced beta-lactamase. Fusobacteria were recovered from 41%; one strain produced beta-lactamase. After administration of phenoxymethylpenicillin in doses of 1 g twice a day for nine days, the beta-streptococci were eliminated, but no change of the amount of S aureus, Hemophilus, Bacteroides, or fusobacteria was seen. Clindamycin in doses of 0.15 g four times daily for nine days diminished almost all bacteria except for the Hemophilus species.
共有75例年龄在15至44岁之间的复发性扁桃体炎患者被分为三组，其中两组在手术前接受了抗生素治疗。在治疗开始前采集细菌学标本，并对切除扁桃体的微生物群落进行分析。在83%的患者扁桃体中发现了拟杆菌属，其中50%的这些微生物是β-内酰胺酶产生菌。发现的其他细菌有金黄色葡萄球菌占45%，A组β-链球菌占4%，C组和G组β-链球菌占24%。嗜血杆菌属从50%的患者中分离出来，但没有菌株产生β-内酰胺酶。梭杆菌属从41%的患者中分离出来；一株产生β-内酰胺酶。每天两次给予1 g剂量的苯氧甲基青霉素，持续九天后，β-链球菌被清除，但金黄色葡萄球菌、嗜血杆菌属、拟杆菌属或梭杆菌属的数量没有变化。每天四次给予0.15 g剂量的克林霉素，持续九天，除嗜血杆菌属外，几乎所有细菌数量都减少了。
