Tunér K, Nord C E
Scand J Infect Dis Suppl. 1983;39:83-5.
In 73% of 167 patients with recurrent tonsillitis, colonization with betalactamase-producing microorganisms was found. Betastreptococci group A were recovered in 6% of the patients and group C and G streptococci in 23%. Other microorganisms found were Staphylococcus aureus in 42%, Haemophilus species in 52%, bacteroides species in 80% and fusobacteria in 40%. Ninety-eight per cent of Staph. aureus, 60% of bacteroides species and 10% of fusobacteria were betalactamase-producing. Phenoxymethylpenicillin (1 g twice a day for ten days) diminished 50% of group A, C and G streptococci. No other microorganisms were affected by this antibiotic. Clindamycin (0.15 g four times a day for ten days) eradicated Staph. aureus, group A, C and G streptococci, bacteroides and fusobacteria. Haemophilus species were not affected by clindamycin. Tinidazole (1 g once a day for 10 days) diminished bacteroides and fusobacteria. Aerobic microorganisms, Staph. aureus, streptococci and Haemophilus, were not affected by tinidazole.
在167例复发性扁桃体炎患者中，73%被发现有产β-内酰胺酶微生物定植。6%的患者分离出A组β溶血性链球菌，23%的患者分离出C组和G组链球菌。其他发现的微生物包括42%的金黄色葡萄球菌、52%的嗜血杆菌属、80%的拟杆菌属和40%的梭杆菌属。98%的金黄色葡萄球菌、60%的拟杆菌属和10%的梭杆菌属产β-内酰胺酶。苯氧甲基青霉素（每日2次，每次1 g，共10天）使A组、C组和G组链球菌数量减少50%。该抗生素对其他微生物无影响。克林霉素（每日4次，每次0.15 g，共10天）根除了金黄色葡萄球菌、A组、C组和G组链球菌、拟杆菌属和梭杆菌属。嗜血杆菌属不受克林霉素影响。替硝唑（每日1次，每次1 g，共10天）减少了拟杆菌属和梭杆菌属数量。需氧微生物，如金黄色葡萄球菌、链球菌和嗜血杆菌属，不受替硝唑影响。
