Fundação Oswaldo Cruz, Instituto Nacional da Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira, Rio de Janeiro, RJ, Brazil.
Rev Paul Pediatr. 2024 Sep 6;43:e2023210. doi: 10.1590/1984-0462/2025/43/2023210. eCollection 2024.
To compare the presence of neutralizing antibodies against SARS-CoV-2 found in the breast milk and blood of vaccinated lactating women with those not vaccinated.
The study was registered in the International Prospective Register of Systematic Reviews (PROSPERO) under CRD42021287554 and followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Cohort, case-control, and cross-sectional studies that evaluated antibodies against SARS-CoV-2 in the milk and blood of vaccinated mothers and had as control group unvaccinated mothers were eligible. Health Sciences Descriptors (DeCs), Medical Subject Headings (MeSH) and Emtree descriptors were used for the Virtual Health Library (VHL), Medical Literature Analysis and Retrieval System Online (Medline/Pubmed), and Embase databases, respectively. In the Web of Science and Scopus, the strategy was adapted. No restrictions on the publication period and language were set.
The search identified 233 records, of which 128 duplicates and 101 papers that did not meet the inclusion criteria were excluded. Hence, four cohort studies were eligible. Nursing mothers vaccinated with the Pfizer-BioNTech and Moderna vaccines showed antibodies against SARS-CoV-2 in their blood and breast milk.
Vaccinated lactating women had higher levels of immunoglobulin G (IgG) and A (IgA) in serum and breast milk than unvaccinated women.
比较接种疫苗的哺乳期妇女的母乳和血液中与未接种疫苗的妇女相比，针对 SARS-CoV-2 的中和抗体的存在情况。
该研究在国际前瞻性系统评价注册库（PROSPERO）中注册，注册号为 CRD42021287554，并遵循系统评价和荟萃分析的首选报告项目（PRISMA）指南。合格的研究包括评估接种母亲母乳和血液中针对 SARS-CoV-2 的抗体的队列、病例对照和横断面研究，对照组为未接种母亲。虚拟健康图书馆（VHL）分别使用健康科学描述符（DeCs）、医学主题词（MeSH）和 Emtree 描述符，医学文献分析和检索系统在线（Medline/Pubmed）和 Embase 数据库。在 Web of Science 和 Scopus 中，采用了相应的策略。未对出版物期限和语言设置限制。
检索共确定了 233 条记录，其中 128 条重复记录和 101 条不符合纳入标准的记录被排除。因此，有 4 项队列研究符合条件。接种辉瑞-生物技术公司和 Moderna 疫苗的哺乳期母亲在其血液和母乳中均显示出针对 SARS-CoV-2 的抗体。
接种疫苗的哺乳期妇女的血清和母乳中免疫球蛋白 G（IgG）和 A（IgA）的水平高于未接种疫苗的妇女。
