Jakuszko Katarzyna, Kościelska-Kasprzak Katarzyna, Żabińska Marcelina, Bartoszek Dorota, Poznański Paweł, Rukasz Dagna, Kłak Renata, Królak-Olejnik Barbara, Krajewska Magdalena
Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, 50-367 Wroclaw, Poland.
Department of Neonatology, Wroclaw Medical University, 50-367 Wroclaw, Poland.
Vaccines (Basel). 2021 Jun 17;9(6):663. doi: 10.3390/vaccines9060663.
Initially, there were no data on the safety of COVID-19 vaccines in lactating women. The aim of our study was to evaluate the immune response to COVID-19 vaccinations in breastfeeding women.
The study included 32 breastfeeding women who, regardless of the study, had decided to be vaccinated. Maternal serum and breast milk samples were simultaneously collected on days 8 ± 1, 22 ± 2, 29 ± 3, and 43 ± 4 after the first dose of the vaccine. The immune response was assessed by determining the presence of anti-SARS-CoV-2 IgG and IgA.
The breast milk IgG level was detectable (6.50 ± 6.74, median 4.7, and maximum 34.2 BAU/mL) and highly correlated to serum IgG level (r 0.89; < 0.001). The breast milk ratio of IgA to the cut-off value was higher in serum IgA-positive (4.18 ± 3.26, median 2.8, and maximum >10) than in serum IgA-negative women (0.56 ± 0.37, median 0.5, and maximum 1.6; < 0.001). The highest concentrations of serum and breast milk antibodies were observed on day 29 ± 3 with a decrease on day 43 ± 4.
The immune response to the vaccination against SARS-CoV-2 is strongest 7 ± 3 days after the second dose of the vaccine. Lactating mothers breastfeeding their children after vaccination against SARS-CoV-2 may transfer antibodies to their infant.
最初，关于新冠病毒疫苗在哺乳期妇女中的安全性尚无数据。我们研究的目的是评估哺乳期妇女对新冠病毒疫苗接种的免疫反应。
该研究纳入了32名哺乳期妇女，她们无论本研究如何，均已决定接种疫苗。在接种第一剂疫苗后的第8±1天、22±2天、29±3天和43±4天同时采集母体血清和母乳样本。通过检测抗SARS-CoV-2 IgG和IgA的存在来评估免疫反应。
母乳中IgG水平可检测到（6.50±6.74，中位数4.7，最大值34.2 BAU/mL），且与血清IgG水平高度相关（r 0.89；<0.001）。血清IgA阳性的女性母乳中IgA与临界值的比值（4.18±3.26，中位数2.8，最大值>10）高于血清IgA阴性的女性（0.56±0.37，中位数0.5，最大值1.6；<0.001）。在第29±3天观察到血清和母乳抗体浓度最高，在第43±4天有所下降。
接种针对SARS-CoV-2疫苗后的免疫反应在第二剂疫苗接种后7±3天最强。接种SARS-CoV-2疫苗后进行母乳喂养的哺乳期母亲可能会将抗体传递给婴儿。
