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热休克蛋白 10 同源蛋白（TCP-1）复合物亚基基因是潜在的预后生物标志物，并与肺腺癌中 Th2 细胞浸润相关：一项观察性研究。

Chaperonin-containing TCP-1 subunit genes are potential prognostic biomarkers and are correlated with Th2 cell infiltration in lung adenocarcinoma: An observational study.

机构信息

Zhang Zhongjing School of Chinese Medicine, Nanyang Institute of Technology, Nanyang, Henan Province, PR China.

Henan Key Laboratory of Zhang Zhongjing Formulae and Herbs for Immunoregulation, Nanyang Institute of Technology, Nanyang, Henan Province, PR China.

出版信息

Medicine (Baltimore). 2024 May 31;103(22):e38387. doi: 10.1097/MD.0000000000038387.

DOI:10.1097/MD.0000000000038387
PMID:39259093
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11142841/
Abstract

A family of molecular chaperone complexes called chaperonin-containing T-complex protein 1 (TCP-1) subunit genes (CCTs) aids in the folding of numerous proteins. With regard to lung adenocarcinoma (LUAD), this study provided a thorough understanding of the diagnostic and prognostic use of CCTs. The expression of CCTs in LUAD was evaluated by using databases including UALCAN and the Gene Expression Omnibus. Immunohistochemistry (IHC) was conducted to validate the expression of CCTs in LUAD. The mutation in the CCTs was identified through the cBioPortal database, while promoter methylation was measured by the UALCAN database. The prognostic value of CCTs was evaluated using the PrognoScan analysis. The GEPIA2.0 database was used to measure the prognostic value of CCTs and associated Hub genes. Correlation analysis between CCTs expression in LUAD was based on the GEPIA2.0 database. The ROC curves, clinical correlation analysis, gene ontology, Kyoto Encyclopedia of Genes and Genome analysis, and immune cell infiltration analysis were downloaded from The Cancer Genome Atlas database and then analyzed and visualized using the R language. The STRING database was used for protein-protein interaction analysis. Upregulation of CCTs expression in patients with LUAD indicated advanced diseases and a poor prognosis. ROC curve analysis revealed that the CCTs may serve as diagnostic indicators. The functional enrichment analysis showed that CCTs were involved in the mitosis-mediated cell cycle process. Additionally, 10 hub genes associated with CCTs that were linked to LUAD prognosis and tumor progression were identified. Immune cell infiltration analysis showed that CCTs expression in tumor tissues tends to be related to T helper type 2 cell infiltration. This study revealed that CCTs may serve as valuable biomarkers for the diagnosis and targeted therapy of LUAD.

摘要

一个名为分子伴侣复合物的家族，称为含 chaperonin 的 T 复合物蛋白 1（TCP-1）亚基基因（CCTs），有助于许多蛋白质的折叠。就肺腺癌（LUAD）而言，本研究深入了解了 CCTs 的诊断和预后用途。使用包括 UALCAN 和基因表达综合数据库在内的数据库评估 LUAD 中 CCTs 的表达。通过免疫组织化学（IHC）验证 LUAD 中 CCTs 的表达。通过 cBioPortal 数据库识别 CCTs 的突变，而通过 UALCAN 数据库测量启动子甲基化。使用 PrognoScan 分析评估 CCTs 的预后价值。使用 GEPIA2.0 数据库测量 CCTs 及其相关 Hub 基因的预后价值。基于 GEPIA2.0 数据库进行 LUAD 中 CCTs 表达的相关性分析。从癌症基因组图谱数据库下载 ROC 曲线、临床相关性分析、基因本体论、京都基因与基因组百科全书分析和免疫细胞浸润分析，并使用 R 语言进行分析和可视化。使用 STRING 数据库进行蛋白质-蛋白质相互作用分析。LUAD 患者中 CCTs 表达上调表明疾病进展和预后不良。ROC 曲线分析表明 CCTs 可能作为诊断指标。功能富集分析表明 CCTs 参与有丝分裂介导的细胞周期过程。此外，确定了 10 个与 CCTs 相关的与 LUAD 预后和肿瘤进展相关的 Hub 基因。免疫细胞浸润分析表明，肿瘤组织中 CCTs 的表达往往与辅助性 T 细胞 2 型细胞浸润有关。本研究表明，CCTs 可能作为 LUAD 诊断和靶向治疗的有价值的生物标志物。

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Anticarin- shows a promising anti-osteosarcoma effect by specifically inhibiting CCT4 to impair proteostasis.Anticarin- 通过特异性抑制 CCT4 损害蛋白质稳态，显示出有前景的抗骨肉瘤作用。
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Suppression of CCT3 Inhibits Tumor Progression by Impairing ATP Production and Cytoplasmic Translation in Lung Adenocarcinoma.CCT3 抑制通过损害肺腺癌中的 ATP 产生和细胞质翻译来抑制肿瘤进展。
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Restraint of chaperonin containing T-complex protein-1 subunit 3 has antitumor roles in non-small cell lung cancer via affection of YAP1.包含T-复合体蛋白1亚基3的伴侣蛋白的抑制通过影响YAP1在非小细胞肺癌中发挥抗肿瘤作用。
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