Department of Cardiology Xishuangbanna Dai Autonomous Prefecture People's Hospital No. 4, Jinghong, Yunnan.
Medicine (Baltimore). 2024 May 31;103(22):e38361. doi: 10.1097/MD.0000000000038361.
The potential role of smoking as a risk factor for thoracic aortic aneurysm is still a subject of debate. Therefore, it is important to systematically investigate the causal relationship between smoking and thoracic aortic aneurysm using Mendelian randomization methods. Genetic data were obtained from genome-wide association studies using the inverse variance weighting method as the primary approach. A thorough sensitivity analysis was conducted to ensure the reliability of the findings. Instrumental variables were assessed using the F statistic, and meta-analysis was employed to assess the average genetic predictive effect between smoking and thoracic aortic aneurysm. Our Mendelian randomization study found a positive association between smoking and thoracic aortic aneurysm. The odds ratios (OR) in the inverse variance weighting method were OR = 1.23 (95% confidence interval [CI] = 1.00-1.51; P = .053) and OR = 2.07 (95% CI = 1.10-3.91; P = .024). Furthermore, meta-analyses consistently demonstrated a positive causal relationship between ferritin and myocardial infarction, although statistical significance was not observed. The analysis results did not indicate any horizontal pleiotropy. Despite the presence of heterogeneity, the Mendelian randomization analysis still yielded significant results. This study employed Mendelian randomization to establish a positive association between smoking levels and the risk of thoracic aortic aneurysm. The genetic evidence reveals a causal relationship between the two, offering new insights for future interventions targeting thoracic aortic aneurysms.
吸烟作为胸主动脉瘤的风险因素的潜在作用仍然存在争议。因此，使用孟德尔随机化方法系统地研究吸烟与胸主动脉瘤之间的因果关系非常重要。使用逆方差加权法从全基因组关联研究中获得遗传数据，作为主要方法。进行了彻底的敏感性分析，以确保研究结果的可靠性。使用 F 统计量评估工具变量，并进行荟萃分析评估吸烟与胸主动脉瘤之间的平均遗传预测效应。我们的孟德尔随机化研究发现吸烟与胸主动脉瘤之间存在正相关。逆方差加权法中的比值比（OR）为 OR = 1.23（95%置信区间 [CI] = 1.00-1.51；P =.053）和 OR = 2.07（95% CI = 1.10-3.91；P =.024）。此外，荟萃分析一致表明，铁蛋白与心肌梗死之间存在正向因果关系，尽管未观察到统计学意义。分析结果并未表明存在水平性多效性。尽管存在异质性，但孟德尔随机化分析仍得出显著结果。本研究采用孟德尔随机化方法，建立了吸烟水平与胸主动脉瘤风险之间的正相关关系。遗传证据揭示了两者之间的因果关系，为未来针对胸主动脉瘤的干预措施提供了新的见解。
