People's Hospital of Xishuangbanna Dai Autonomous Prefecture, Jinghong, Yunnan, China.
Medicine (Baltimore). 2024 Apr 26;103(17):e37952. doi: 10.1097/MD.0000000000037952.
The potential role of serum ferritin as a risk factor for myocardial infarction (MI) is controversial, necessitating a systematic exploration of the causal relationship between ferritin and MI through Mendelian randomization (MR) methods. Genetic data were derived from a genome-wide association study (GWAS), employing the inverse variance-weighted (IVW) method as the primary approach. Comprehensive sensitivity analyses were conducted to validate the robustness of the results. Evaluation of instrumental variables was performed using the F-statistic, and a meta-analysis was employed to assess the average gene-predicted effect between ferritin and MI. The MR study revealed a negative correlation between ferritin and MI. The odds ratios (ORs) in the IVW method were 0.83 [95% confidence interval (CI) = 0.72-0.97; P = .017] and 0.86 (95% CI = 0.72-1.02; P = .080). Additionally, meta-analysis consistently indicated a negative causal relationship between ferritin and MI, with no heterogeneity or horizontal pleiotropy, thereby indicating a negative correlation between ferritin levels and the risk of MI. The genetic evidence sheds light on the causal relationship between ferritin levels and MI risk, providing new perspectives for future interventions in acute myocardial infarction (AMI).
血清铁蛋白作为心肌梗死 (MI) 风险因素的潜在作用存在争议，因此需要通过孟德尔随机化 (MR) 方法系统探索铁蛋白与 MI 之间的因果关系。遗传数据源自全基因组关联研究 (GWAS)，采用逆方差加权 (IVW) 法作为主要方法。综合敏感性分析用于验证结果的稳健性。使用 F 统计量评估工具变量，并采用荟萃分析评估铁蛋白与 MI 之间的平均基因预测效应。MR 研究表明铁蛋白与 MI 呈负相关。IVW 法中的比值比 (OR) 为 0.83 [95%置信区间 (CI) = 0.72-0.97; P =.017] 和 0.86 (95% CI = 0.72-1.02; P =.080)。此外，荟萃分析一致表明铁蛋白与 MI 之间存在负向因果关系，无异质性或水平多效性，表明铁蛋白水平与 MI 风险之间呈负相关。遗传证据阐明了铁蛋白水平与 MI 风险之间的因果关系，为急性心肌梗死 (AMI) 的未来干预提供了新视角。
