一个新的参与者在溶酶体相关细胞器的生物发生中。

A new player in the biogenesis of lysosome-related organelles.

机构信息

Department of Biochemistry and Molecular Biology, School of Basic Medicine, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease, Huazhong University of Science and Technology, Wuhan, China.

Cell Architecture Research Center, Huazhong University of Science and Technology , Wuhan, China.

出版信息

J Cell Biol. 2024 Oct 7;223(10). doi: 10.1083/jcb.202407194. Epub 2024 Sep 11.

DOI:10.1083/jcb.202407194

PMID:39259305

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11393562/

Abstract

How are Rab GTPases regulated during lysosome-related organelle (LRO) biogenesis? Li et al. (https://doi.org/10.1083/jcb.202402016) identify LYSMD proteins as crucial activators of Rab32-family GTPases in LRO development, shedding light on the previously ambiguous mechanisms governing Rab functionality in this process.

摘要

Rab GTPases 在溶酶体相关细胞器 (LRO) 发生过程中是如何被调控的？Li 等人（https://doi.org/10.1083/jcb.202402016）发现 LYSMD 蛋白是 LRO 发育过程中 Rab32 家族 GTPases 的关键激活因子，这为之前在这一过程中调控 Rab 功能的机制不明确的问题提供了线索。