Université Côte d'Azur, LAMHESS, Nice, France.
Université Côte d'Azur, Centre Hospitalier Universitaire de Nice, Clinique Gériatrique du Cerveau et du Mouvement, Nice, France.
Aging Clin Exp Res. 2024 Sep 11;36(1):190. doi: 10.1007/s40520-024-02829-0.
Idiopathic normal pressure hydrocephalus (iNPH) is a prevalent neurological disorder, but its diagnosis remains challenging. Dual-task (DT) walking performance is a reliable indicator of iNPH but less is known about the role of cognitive reserve (CR) in predicting DT walking performance.
The objective of this study was to evaluate the contribution of CR on DT walking in healthy controls (HC) and in iNPH patients (iNPH-P).
68 iNPH-P (77.2 +/- 6.7 years old) and 28 HC (74.5 +/- 5.7 years old) were evaluated on their single-task walking (Vsimple) and on 4 DT walking (walking and counting or counting backwards, naming animals, naming words beginning with the letter P) (Vcount, VcountB, Vanimals and Vletter respectively). The contribution of CR on the different DT walking speeds was compared between HC and iNPH-P. In iNPH-P, the contribution of CR on the walking speeds was compared with regard to other cognitive, functional, and socio-demographic variables.
Simple linear regression demonstrated a moderate influence of CR on single and DT walking speed in iNPH-P (β > 0.3, p < .001) but not in HC where the relation was not significant. In iNPH-P, results showed that CR played a major role in explaining each of the single and DT walking speeds with NPH-scale.
As CR could be improved through the life cycle, these results support the idea of developing and supporting physical activity programs that will enrich social, physical, and cognitive resources to protect against age-related functional decline, especially in iNPH-P patients where the age-related deficits are greater.
特发性正常压力脑积水（iNPH）是一种常见的神经退行性疾病，但诊断仍然具有挑战性。双重任务（DT）步行表现是 iNPH 的可靠指标，但对认知储备（CR）在预测 DT 步行表现中的作用知之甚少。
本研究旨在评估 CR 在健康对照组（HC）和 iNPH 患者（iNPH-P）的 DT 步行中的作用。
对 68 名 iNPH-P（77.2±6.7 岁）和 28 名 HC（74.5±5.7 岁）进行单任务步行（Vsimple）和 4 项 DT 步行（步行和计数或倒数计数、命名动物、以字母 P 开头的单词命名）（Vcount、VcountB、Vanimals 和 Vletter）的评估。比较 HC 和 iNPH-P 之间 CR 对不同 DT 步行速度的贡献。在 iNPH-P 中，比较 CR 对行走速度的贡献与其他认知、功能和社会人口统计学变量。
简单线性回归表明，CR 对 iNPH-P 的单任务和 DT 步行速度有中等影响（β>0.3，p<0.001），但在 HC 中没有显著关系。在 iNPH-P 中，结果表明 CR 在解释 NPH 量表中的每个单任务和 DT 步行速度方面起着主要作用。
由于 CR 可以通过生命周期得到改善，这些结果支持通过开发和支持体育活动计划来增强社会、身体和认知资源的想法，以防止与年龄相关的功能下降，特别是在 iNPH-P 患者中，这些患者的年龄相关缺陷更大。
