β1 选择性肾上腺素能受体阻断对运动生理反应的影响。
Effect of beta1 selective adrenoceptor blockade on physiological response to exercise.
作者信息
Gordon N F, van Rensburg J P, Russell H M, Kawalsky D L, Celliers C P, Cilliers J F, Myburgh D P
出版信息
Br Heart J. 1985 Jul;54(1):96-9. doi: 10.1136/hrt.54.1.96.
The effect of the beta1 selective adrenoceptor blocker, atenolol, on the physiological response to exercise was studied in 12 healthy young men. Oral atenolol (100 mg) and placebo were administered in a randomised double blind crossover fashion an hour and a half before an intermittent multistage cycle ergometer exercise test. At maximal effort oxygen consumption, pulmonary ventilation, carbon dioxide output, and respiratory exchange ratio were not modified by atenolol. In contrast, maximal heart rate and performance time were significantly reduced after atenolol. Nevertheless, because the relation of percentage of maximal oxygen consumption to percentage of maximal heart rate was not changed by atenolol both the absolute and relative oxygen consumption corresponding to 70% and 85% of the maximal heart rate remained unaltered. These data suggest that recommendations of exercise intensity may be determined on the basis of a calculated percentage of the predetermined maximal heart rate in persons without symptomatic coronary heart disease receiving beta1 selective adrenoceptor blockers.
在12名健康年轻男性中研究了β1选择性肾上腺素能受体阻滞剂阿替洛尔对运动生理反应的影响。在间歇性多级自行车测力计运动试验前一个半小时，以随机双盲交叉方式给予口服阿替洛尔（100毫克）和安慰剂。在最大运动量时，阿替洛尔未改变耗氧量、肺通气量、二氧化碳排出量和呼吸交换率。相比之下，阿替洛尔使最大心率和运动时间显著降低。然而，由于阿替洛尔未改变最大耗氧量百分比与最大心率百分比之间的关系，对应于最大心率70%和85%的绝对和相对耗氧量保持不变。这些数据表明，对于无症状冠心病且正在接受β1选择性肾上腺素能受体阻滞剂治疗的患者，运动强度建议可根据预先确定的最大心率的计算百分比来确定。
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