利用磺胺类药物的 pH 值依赖光谱修饰来设计分子逻辑门。

Utilizing sulfa drugs' pH-dependent spectral modifications for designing molecular logic gates.

机构信息

Department of Physics, Vijayanagara Sri Krishnadevaraya University, Ballari 583 105, India.

Department of Physics, Siddaganga Institute of Technology, Tumakuru, Karnataka 572103, India.

出版信息

Spectrochim Acta A Mol Biomol Spectrosc. 2025 Jan 15;325:125099. doi: 10.1016/j.saa.2024.125099. Epub 2024 Sep 6.

DOI:10.1016/j.saa.2024.125099

PMID:39260243

Abstract

In this study, the absorption and fluorescence characteristics of sulfa drugs, specifically Sulfadiazine (SDZ), Sulfamerazine (SMZ), and Sulfamethazine (STZ), were examined across a pH range of 1-14. The absorption and fluorescence spectra of these sulfa drugs showed significant changes depending on the pH value. Analysis of their pH-dependent absorption and fluorescence properties indicated that these sulfa drugs could used to design molecular logic gates. The absorption and fluorescence behaviors at various wavelength maxima were utilized to design IMPLICATION and Improved-INHIBIT (I-INHIBIT) molecular logic gates.

摘要

在这项研究中，研究人员检测了磺胺类药物（磺胺嘧啶、磺胺甲恶唑和磺胺间甲氧嘧啶）在 pH 值为 1-14 范围内的吸收和荧光特性。这些磺胺类药物的吸收和荧光光谱随 pH 值的变化而发生显著变化。对其 pH 值依赖性吸收和荧光特性的分析表明，这些磺胺类药物可用于设计分子逻辑门。通过利用在不同波长最大值处的吸收和荧光行为，设计了蕴涵和改进型抑制（I-INHIBIT）分子逻辑门。