Behrad Samira, Dezfuli Seyed Ashkan Tabibzadeh, Yazdani Reza, Hayati Saeed, Shanjani Sanaz Mirzayan
Department of Oral and Maxillofacial Pathology, Dental School, Semnan University of Medical Sciences, Semnan, Iran.
Department of Emergency Medicine, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Exp Gerontol. 2024 Oct 15;196:112579. doi: 10.1016/j.exger.2024.112579. Epub 2024 Sep 11.
Vascular endothelial growth factor (VEGF), brain-derived neurotrophic factor (BDNF), and insulin-like growth factor-1 (IGF-1) may help the brain resist both functional and structural neurodegeneration, which is critical for maintaining cognitive and neurological health in older adults. This meta-analysis and meta-regression seek to elucidate the impact of physical activity on these biomarker levels in healthy seniors, as well as to examine the influence of several moderator factors, including age, sex, period length, and time, for the first time. The standardized mean effect metric was used to assess the influence of weights, which reflected each group's relative importance in comparison to baseline data. The study looked at potential moderating factors including age, gender, and physical activity levels. The analysis of 11 studies indicated no significant effect of physical activity on VEGF levels [0.328, CI 95 % (-0.871 to 1.52); I = 0.00; p = 0.592; Q = 4.14]. Physical activity had a substantial impact on brain-derived neurotrophic factor (0.827, 95 % confidence interval: 0.487 to 1.16; I = 0.00; p = 0.00; Q = 78.46), with females showing particularly notable effects (Tau = 0.327, Tau = 0.571, I = 80.90 %, Q = 68.05, df = 15, p = 0.00). Physical activity also had a substantial effect on insulin-like growth factor 1 (0.276, 95 % confidence interval: 0.065 to 0.487; I = 0.00; p = 0.10; Q = 8.35), indicating that it positively influences IGF-1 levels. Overall, while physical exercise has a significant effect on BDNF and IGF-1, more research is needed to fully understand its impact on vascular endothelial growth factor and to investigate how individual characteristics may influence exercise outcomes.
血管内皮生长因子（VEGF）、脑源性神经营养因子（BDNF）和胰岛素样生长因子-1（IGF-1）可能有助于大脑抵抗功能性和结构性神经退行性变，这对维持老年人的认知和神经健康至关重要。这项荟萃分析和荟萃回归旨在阐明体育活动对健康老年人这些生物标志物水平的影响，并首次研究包括年龄、性别、周期长度和时间在内的几个调节因素的影响。标准化平均效应指标用于评估权重的影响，权重反映了每组与基线数据相比的相对重要性。该研究考察了包括年龄、性别和体育活动水平在内的潜在调节因素。对十一项研究的分析表明，体育活动对VEGF水平没有显著影响[0.328，95%置信区间（-0.871至1.52）；I = 0.00；p = 0.592；Q = 4.14]。体育活动对脑源性神经营养因子有显著影响（0.827，95%置信区间：0.487至1.16；I = 0.00；p = 0.00；Q = 78.46），女性的影响尤为显著（Tau = 0.327，Tau = 0.571，I = 80.90%，Q = 68.05，自由度 = 15，p = 0.00）。体育活动对胰岛素样生长因子1也有显著影响（0.276，95%置信区间：0.065至0.487；I = 0.00；p = 0.10；Q = 8.35），表明它对IGF-1水平有积极影响。总体而言，虽然体育锻炼对BDNF和IGF-1有显著影响，但仍需要更多研究来充分了解其对血管内皮生长因子的影响，并研究个体特征如何影响运动效果。
