Department of Endocrinology, Diabetes, Nutrition & Weight Management, Boston University School of Medicine (BUSM), Boston, MA, USA.
Framingham Heart Study, Framingham, MA, USA.
J Diabetes Res. 2019 Jan 9;2019:2718465. doi: 10.1155/2019/2718465. eCollection 2019.
Circulating insulin-like growth factor- (IGF-) 1, vascular endothelial growth factor (VEGF), and brain-derived neurotrophic factor (BDNF) levels are often lower in individuals with diabetes mellitus (DM) and are important for repairing vascular and neuronal dysfunction. The purpose of this investigation was to determine the cross-sectional relations of physical activity to circulating concentrations of IGF-1, VEGF, and BDNF in individuals with and without DM.
In 1730 participants from the Framingham Offspring Study examination cycle 7, including those with DM ( = 179, mean age 64 years, 39% women) and without DM ( = 1551, mean age 60 years, 46% women), we related self-reported physical activity variables to circulating concentrations of IGF-1, VEGF, and BDNF using linear multivariable regression models. We also tested for interactions by age. Participants with prevalent cardiovascular disease, stroke, and dementia or taking hormone replacement therapy were excluded.
In participants with DM, more ambulatory physical activity was associated with higher IGF-1 levels ( ± standard error (SE) = 0.22 ± 0.08, = 0.009), and more total physical activity was related to higher BDNF levels ( ± SE = 0.18 ± 0.08, = 0.035), but physical activity was not significantly related to circulating VEGF. In participants without DM, no associations were observed. Moreover, in the examination of interactions by age, the association of ambulatory physical activity with IGF-1 levels was only observed in older adults with DM (age ≥ 60 years, ± SE = 0.23 ± 0.11, = 0.042) but not in middle-aged adults with DM (age < 60 years, ± SE = 0.06 ± 0.13, = 0.645).
Our results suggest that more physical activity is associated with higher circulating IGF-1 and BDNF in participants with DM. These results, dissecting interactions by both age and DM status, may also help to explain some of the inconsistent results in studies relating physical activity to growth and neurotrophic factors.
循环胰岛素样生长因子-1（IGF-1）、血管内皮生长因子（VEGF）和脑源性神经营养因子（BDNF）水平在糖尿病患者中通常较低，对于修复血管和神经元功能障碍很重要。本研究旨在确定体力活动与有或无糖尿病患者循环 IGF-1、VEGF 和 BDNF 浓度的横断面关系。
在弗雷明汉后代研究检查周期 7 的 1730 名参与者中，包括糖尿病患者（n=179，平均年龄 64 岁，39%为女性）和无糖尿病患者（n=1551，平均年龄 60 岁，46%为女性），我们使用线性多变量回归模型将自我报告的体力活动变量与循环 IGF-1、VEGF 和 BDNF 浓度相关联。我们还通过年龄测试了交互作用。排除了有心血管疾病、中风和痴呆病史或正在接受激素替代治疗的参与者。
在糖尿病患者中，更多的步行体力活动与更高的 IGF-1 水平相关（ ± 标准误差（SE）=0.22 ± 0.08， =0.009），更多的总体力活动与更高的 BDNF 水平相关（ ± SE=0.18 ± 0.08， =0.035），但体力活动与循环 VEGF 无显著相关性。在无糖尿病患者中，未观察到相关性。此外，在年龄交互作用的检查中，步行体力活动与 IGF-1 水平的关联仅在糖尿病的老年患者中观察到（年龄≥60 岁， ± SE=0.23 ± 0.11， =0.042），但在糖尿病的中年患者中未观察到（年龄<60 岁， ± SE=0.06 ± 0.13， =0.645）。
我们的结果表明，更多的体力活动与糖尿病患者循环中更高的 IGF-1 和 BDNF 水平相关。这些结果，通过年龄和糖尿病状态的交互作用进行细分，也有助于解释一些与体力活动与生长和神经营养因子相关的研究中不一致的结果。
