胃癌手术患者术前康复治疗效果的系统评价和荟萃分析方案。
Effect of prehabilitation for patients undergoing gastric cancer surgery: a protocol of a systematic review and meta-analysis.
机构信息
Department of Public Service, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China.
China Medical University, Shenyang, Liaoning Province, China.
出版信息
BMJ Open. 2024 Sep 10;14(9):e083914. doi: 10.1136/bmjopen-2024-083914.
INTRODUCTION
Gastric cancer is a high-risk cancer with surgical treatments often leading to significant postoperative complications and mortality. Prehabilitation, involving exercise, nutrition and psychological support before surgery, aims to boost patients' physical and mental health. While effective in other cancers, its benefits for gastric cancer need further study. This research will evaluate the impact of trimodal prehabilitation on patient outcomes in gastric cancer surgery, aiming to reduce complications and expedite recovery.
METHODS AND ANALYSIS
This study will systematically review randomised controlled trials and cohort studies evaluating the role of prehabilitation in people undergoing gastric cancer resection. The primary outcomes of interest will include overall postoperative complications and length of hospital stay. The secondary outcomes of interest will include mortality, readmission rate or functional recovery. Databases including PubMed, EMBASE, CINAHL, CENTRAL, Chinese BioMedical Literature Database (CBM), Chinese National Knowledge Infrastructure (CNKI), Wanfang database and Chinese Science and Technology Periodicals (VIP) will be searched. All studies will be screened and selected using the criteria described in 'population, intervention/exposure, comparison, outcome and study design' format. Two independent reviewers will screen studies for relevance and methodological validity. Data from included studies will be extracted through a customised, preset data extraction sheet. The Cochrane Review Manager (V.5.3, Nordic Cochrane Centre, Copenhagen, Denmark) software will be used to perform the meta-analysis.
ETHICS AND DISSEMINATION
Ethics approval is not required for this study as all results will be based on published papers. No primary data collection will be needed. Study findings will be presented at scientific conferences or published in a peer-reviewed scientific journal.
PROSPERO REGISTRATION NUMBER
CRD42023488469.
简介
胃癌是一种高风险的癌症，手术治疗常常导致严重的术后并发症和死亡率。术前康复包括手术前的锻炼、营养和心理支持，旨在增强患者的身心健康。虽然在其他癌症中有效，但它对胃癌的益处需要进一步研究。这项研究将评估三模态术前康复对胃癌手术患者结局的影响，旨在减少并发症并加速康复。
方法和分析
本研究将系统综述评价术前康复在接受胃癌切除术的人群中作用的随机对照试验和队列研究。主要观察结果将包括总体术后并发症和住院时间。次要观察结果将包括死亡率、再入院率或功能恢复。将检索包括 PubMed、EMBASE、CINAHL、CENTRAL、中国生物医学文献数据库（CBM）、中国国家知识基础设施（CNKI）、万方数据库和中国科技期刊数据库（VIP）在内的数据库。将使用“人群、干预/暴露、比较、结局和研究设计”格式描述的标准筛选和选择所有研究。两名独立评审员将根据相关性和方法学有效性筛选研究。将通过定制的预设数据提取表提取纳入研究的数据。将使用 Cochrane 评论经理（V.5.3，北欧 Cochrane 中心，哥本哈根，丹麦）软件进行荟萃分析。
伦理和传播
本研究不需要伦理批准，因为所有结果都将基于已发表的论文。不需要进行原始数据收集。研究结果将在科学会议上展示或发表在同行评议的科学期刊上。
PROSPERO 注册号：CRD42023488469。
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