University of Stirling, Stirling, UK
University of Stirling, Stirling, UK.
BMJ Open. 2024 Sep 10;14(9):e082424. doi: 10.1136/bmjopen-2023-082424.
Hypertensive disorders of pregnancy (HDP) are one of the leading causes of maternal morbidity and mortality. The risk of developing cardiovascular diseases following HDP is high. Arterial stiffness is a prognostic indicator for cardiovascular disease in the general population, and it is elevated during pregnancy in women with HDP. No systematic reviews have been conducted to determine if arterial stiffness remains elevated beyond puerperium in these women with HDP.
We will conduct a systematic literature search in the following electronic databases: Medline, PubMed, Embase, Cochrane Library, Google Scholar, Web of Science and CINAHL. The review will consider studies that investigate arterial stiffness in women who had HPD and are between 43 days and 10 years postdelivery and under 60 years of age. This systematic review will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols guidelines. Estimates of mean ± SD for arterial stiffness indices (cfPWV, AIx and AIx@75) for the women in the included studies will be obtained. For studies where the estimates were reported as the median and IQR, approximate estimates of mean ± SD will be calculated by using the low and high end of the range, median and sample size. Data from the individual studies will be pooled by use of a random-effects model. The risk of bias assessment will be assessed using the Cochrane Collaboration tool and the Newcastle-Ottawa Quality Assessment Scale as appropriate. Sources of heterogeneity will be explored by sensitivity and subgroup analyses.
No ethics approval is required as only published data will be used in this study. The research study's outcomes will be shared through scientific conferences and peer-reviewed publications.
CRD42023461867.
妊娠高血压疾病（HDP）是孕产妇发病率和死亡率的主要原因之一。HDP 患者发生心血管疾病的风险较高。动脉僵硬度是一般人群心血管疾病的预后指标，在 HDP 孕妇怀孕期间会升高。目前尚未进行系统评价来确定 HDP 患者在产后是否仍存在动脉僵硬度升高的情况。
我们将在以下电子数据库中进行系统文献检索：Medline、PubMed、Embase、Cochrane 图书馆、Google Scholar、Web of Science 和 CINAHL。本综述将考虑研究 HPD 后 43 天至 10 年且年龄在 60 岁以下的女性动脉僵硬度的研究。本系统评价将遵循《系统评价和荟萃分析报告规范》的建议。将获得纳入研究中女性的动脉僵硬度指标（cfPWV、AIx 和 AIx@75）的均值 ± SD 估计值。对于以中位数和 IQR 报告估计值的研究，将使用范围的低端和高端、中位数和样本量计算均值 ± SD 的近似估计值。将使用随机效应模型对来自各个研究的数据进行汇总。将使用 Cochrane 协作工具和适当的纽卡斯尔-渥太华质量评估量表评估偏倚风险，并通过敏感性和亚组分析探索异质性来源。
由于本研究仅使用已发表的数据，因此不需要伦理批准。研究结果将通过科学会议和同行评审出版物进行分享。
PROSPERO 注册号：CRD42023461867。
