Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.
Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.
BMJ Open. 2024 May 17;14(5):e080322. doi: 10.1136/bmjopen-2023-080322.
Bell's palsy is an idiopathic peripheral nerve palsy involving the facial nerve. Pregnancy, diabetes mellitus and hypertension are the risk factors for Bell's palsy. However, the association between hypertensive disorders and Bell's palsy during pregnancy or the puerperium remains unclear. This systematic review will comprehensively summarise the literature and evaluate the association between Bell's palsy and hypertensive disorders during pregnancy or the puerperium.
Systematic searches of PubMed, MEDLINE, EMBASE and the Cochrane Central Register of Controlled Trials will be undertaken using prespecified search strategies. Observational studies (cross-sectional studies, cohort studies, case reports and series case reports) written in English that investigate the association between hypertensive disorders of late pregnancy and Bell's palsy during pregnancy or the puerperium will be included. Different authors will independently conduct the eligible study selection, perform data extraction and appraise the quality of included studies. Subgroup analysis will be carried out based on the age of pregnant women (≤35 years old, >35 years old), parity (primipara, multipara) and fetus number (singleton or multiple-gestation pregnancy).
This review will be based on published literature, and thus there is no requirement for ethics approval. The results of this study will aid in the knowledge of the relationship between Bell's palsy during pregnancy or the puerperium and hypertensive disorders of late pregnancy. The results of this systematic review will be shared through publication in a peer-reviewed journal with good visibility for the field of obstetrics and presentations at academic conferences.
CRD42023422902.
贝尔氏麻痹是一种特发性周围性面神经麻痹，涉及面神经。妊娠、糖尿病和高血压是贝尔氏麻痹的危险因素。然而，妊娠或产褥期高血压与贝尔氏麻痹之间的关联尚不清楚。本系统评价将全面总结文献，评估妊娠或产褥期高血压与贝尔氏麻痹之间的关联。
系统检索 PubMed、MEDLINE、EMBASE 和 Cochrane 对照试验中心注册库，使用预设的检索策略。纳入使用英语撰写的、调查晚期妊娠高血压与妊娠或产褥期贝尔氏麻痹之间关联的观察性研究（横断面研究、队列研究、病例报告和系列病例报告）。不同的作者将独立进行合格研究的选择、数据提取和纳入研究质量评估。将根据孕妇年龄（≤35 岁，>35 岁）、产次（初产妇、经产妇）和胎儿数量（单胎或多胎妊娠）进行亚组分析。
本综述将基于已发表的文献，因此无需伦理批准。本研究的结果将有助于了解妊娠或产褥期贝尔氏麻痹与晚期妊娠高血压之间的关系。本系统评价的结果将通过发表在同行评议的期刊上并在妇产科会议上展示来共享。
CRD42023422902。
