Kawakami-Shinoda Yuka, Sato Megumi, Bao Alima, Zheng Xiangna, Kamiya Mana, Li Ge, Hosaka Toshio, Goda Toshinao, Arai Hidekazu
Laboratory of Clinical Nutrition and Management, Graduate Division of Nutritional and Environmental Sciences, and Graduate School of Integrated Pharmaceutical and Nuritional Sciences, The University of Shizuoka.
Laboratory of Clinical Nutrition, Graduate Division of Nutritional and Environmental Sciences, and Graduate School of Integrated Pharmaceutical and Nutritional Sciences, The University of Shizuoka.
J Atheroscler Thromb. 2025 Mar 1;32(3):356-366. doi: 10.5551/jat.64509. Epub 2024 Oct 25.
We aimed to elucidate the effect of a healthy diet containing adequate amounts of protein and vegetables on metabolic indices.
In this randomized crossover study, twenty-two healthy Japanese participants ingested two different test meals: fish diet (F) or fish diet with adequate vegetable content (FV). Each 5-day diet load test was separated by a washout period of at least seven days. Metabolic indices were measured in fasting blood and 24-h urine samples.
The delta (Δ) plasma glucose and Δserum low-density lipoprotein (LDL) cholesterol concentrations were significantly larger in the participants in group FV than in group F (p=0.042, p=0.013, respectively). The urinary pH in participants in group F on day 6 was significantly lower than on day 1 (p=0.008), and the Δurinary pH and Δnet gastrointestinal absorption of alkali of participants in group FV tended to be smaller than in group F (p=0.070, p=0.075, respectively).
This study showed that a healthy diet containing adequate protein and vegetables reduced the dietary acid load and improved plasma glucose and serum LDL concentrations in healthy Japanese participants.
我们旨在阐明含有适量蛋白质和蔬菜的健康饮食对代谢指标的影响。
在这项随机交叉研究中，22名健康的日本参与者摄入两种不同的测试餐：鱼类饮食（F）或蔬菜含量充足的鱼类饮食（FV）。每次为期5天的饮食负荷测试之间间隔至少7天的洗脱期。在空腹血液和24小时尿液样本中测量代谢指标。
FV组参与者的血浆葡萄糖增量（Δ）和血清低密度脂蛋白（LDL）胆固醇增量显著大于F组（分别为p = 0.042，p = 0.013）。F组参与者第6天的尿液pH值显著低于第1天（p = 0.008），FV组参与者的尿液pH值增量和碱的胃肠道净吸收增量往往小于F组（分别为p = 0.070，p = 0.075）。
本研究表明，含有适量蛋白质和蔬菜的健康饮食可降低健康日本参与者的饮食酸负荷，并改善血浆葡萄糖和血清LDL浓度。
