Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Nat Commun. 2024 Sep 11;15(1):7952. doi: 10.1038/s41467-024-51824-6.
The relationship between psoriasis and site-specific cancers remains unclear. Here, we aim to investigate whether psoriasis is causally associated with site-specific cancers. We use observational and genetic data from the UK Biobank, obtaining GWAS summary data, eQTL analysis data, TCGA data, and GTEx data from public datasets. We perform PheWAS, polygenic risk score analysis, and one-sample and two-sample Mendelian randomization analyses to investigate the potential causal associations between psoriasis and cancers. In the unselected PheWAS analysis, psoriasis is associated with higher risks of 16 types of cancer. Using one-sample Mendelian randomization analyses, it is found that genetically predicted psoriasis is associated with higher risks of anal canal cancer, breast cancer, follicular non-Hodgkin's lymphoma and nonmelanoma skin cancer in women; and lung cancer and kidney cancer in men. Our two-sample Mendelian randomization analysis indicates that psoriasis is causally associated with breast cancer and lung cancer. Gene annotation shows that psoriasis-related genes, such as ERAP1, are significantly different in lung and breast cancer tissues. Taken together, clinical attention to lung cancer and breast cancer may be warranted among patients with psoriasis.
银屑病与特定部位癌症之间的关系尚不清楚。在这里，我们旨在研究银屑病是否与特定部位的癌症有因果关系。我们使用来自英国生物银行的观察性和遗传数据，从公共数据库中获取 GWAS 汇总数据、eQTL 分析数据、TCGA 数据和 GTEx 数据。我们进行 PheWAS、多基因风险评分分析、单样本和双样本 Mendelian 随机化分析，以研究银屑病与癌症之间潜在的因果关系。在未选择的 PheWAS 分析中，银屑病与 16 种癌症的更高风险相关。使用单样本 Mendelian 随机化分析，发现遗传预测的银屑病与女性的肛门癌、乳腺癌、滤泡性非霍奇金淋巴瘤和非黑色素瘤皮肤癌以及男性的肺癌和肾癌风险增加相关。我们的两样本 Mendelian 随机化分析表明，银屑病与乳腺癌和肺癌有因果关系。基因注释表明，与银屑病相关的基因，如 ERAP1，在肺癌和乳腺癌组织中存在显著差异。综上所述，银屑病患者可能需要关注肺癌和乳腺癌。
