Center for Cardiovascular Diseases, Meizhou People's Hospital, Meizhou Academy of Medical Sciences, Meizhou, China.
Data Center, Meizhou People's Hospital, Meizhou Academy of Medical Sciences, Meizhou, China.
BMC Cardiovasc Disord. 2024 Sep 12;24(1):486. doi: 10.1186/s12872-024-04169-3.
Apolipoprotein E (APOE) gene polymorphisms were associated with coronary atherosclerosis and hypertension. However, the relationship between APOE polymorphisms and coronary atherosclerosis susceptibility in hypertensive patients is unclear. The aim of this study was to assess the relationship.
A total of 1713 patients with hypertension who were admitted to Meizhou People's Hospital from November 2019 to August 2023 were retrospectively analyzed, including 848 patients with coronary atherosclerosis and 865 patients without coronary atherosclerosis. The rs429358 and rs7412 polymorphisms of APOE were genotyped, and relationship between APOE polymorphisms and the risk of coronary atherosclerosis in hypertensive patients were analyzed.
There were 10 (0.6%), 193 (11.3%), 30 (1.8%), 1234 (72.0%), 233 (13.6%), and 13 (0.8%) individuals with APOE ɛ2/ɛ2, ɛ2/ɛ3, ɛ2/ɛ4, ɛ3/ɛ3, ɛ3/ɛ4, and ɛ4/ɛ4 genotype, respectively. The frequency of APOE ɛ3/ɛ4 was higher (16.4% vs. 10.9%, p = 0.001) in the patients with coronary atherosclerosis than controls. Logistic analysis showed that body mass index (BMI) ≥ 24.0 kg/m (24.0 kg/m vs. 18.5-23.9 kg/m, odds ratio (OR): 1.361, 95% confidence interval (CI): 1.112-1.666, p = 0.003), advanced age (≥ 65/<65, OR:1.303, 95% CI: 1.060-1.602, p = 0.012), history of smoking (OR: 1.830, 95% CI: 1.379-2.428, p < 0.001), diabetes mellitus (OR: 1.380, 95% CI: 1.119-1.702, p = 0.003), hyperlipidemia (OR: 1.773, 95% CI: 1.392-2.258, p < 0.001), and APOE ɛ3/ɛ4 genotype (ɛ3/ɛ4 vs. ɛ3/ɛ3, OR: 1.514, 95% CI: 1.133-2.024, p = 0.005) were associated with coronary atherosclerosis in hypertensive patients.
Overweight (BMI ≥ 24.0 kg/m), advanced age, history of smoking, diabetes mellitus, and APOE ɛ3/ɛ4 genotype were independent risk factors for coronary atherosclerosis in hypertensive patients.
载脂蛋白 E (APOE) 基因多态性与冠状动脉粥样硬化和高血压有关。然而，APOE 多态性与高血压患者发生冠状动脉粥样硬化易感性之间的关系尚不清楚。本研究旨在评估这种关系。
回顾性分析 2019 年 11 月至 2023 年 8 月期间梅州市人民医院收治的 1713 例高血压患者的资料，包括 848 例冠状动脉粥样硬化患者和 865 例无冠状动脉粥样硬化患者。对 APOE 的 rs429358 和 rs7412 多态性进行基因分型，并分析 APOE 多态性与高血压患者发生冠状动脉粥样硬化的风险之间的关系。
分别有 10（0.6%）、193（11.3%）、30（1.8%）、1234（72.0%）、233（13.6%）和 13（0.8%）例患者携带 APOE ɛ2/ɛ2、ɛ2/ɛ3、ɛ2/ɛ4、ɛ3/ɛ3、ɛ3/ɛ4 和 ɛ4/ɛ4 基因型。与对照组相比，冠状动脉粥样硬化患者中 APOE ɛ3/ɛ4 基因型的频率更高（16.4%比 10.9%，p=0.001）。Logistic 分析显示，体重指数（BMI）≥24.0 kg/m²（24.0 kg/m²比 18.5-23.9 kg/m²，比值比（OR）：1.361，95%置信区间（CI）：1.112-1.666，p=0.003）、年龄较大（≥65/<65，OR：1.303，95%CI：1.060-1.602，p=0.012）、吸烟史（OR：1.830，95%CI：1.379-2.428，p<0.001）、糖尿病（OR：1.380，95%CI：1.119-1.702，p=0.003）、高脂血症（OR：1.773，95%CI：1.392-2.258，p<0.001）和 APOE ɛ3/ɛ4 基因型（ɛ3/ɛ4 比 ɛ3/ɛ3，OR：1.514，95%CI：1.133-2.024，p=0.005）与高血压患者的冠状动脉粥样硬化有关。
超重（BMI≥24.0 kg/m²）、年龄较大、吸烟史、糖尿病和 APOE ɛ3/ɛ4 基因型是高血压患者发生冠状动脉粥样硬化的独立危险因素。
