基因ε4等位基因与多个血管床的动脉粥样硬化相关。

Gene ε4 Allele is Associated with Atherosclerosis in Multiple Vascular Beds.

作者信息

Lin Youni, Yang Min, Liu Qifeng, Cai Yufu, Zhang Zhouhua, Xu Chongfei, Luo Ming

机构信息

Center for Cardiovascular Diseases, Meizhou People's Hospital, Meizhou, People's Republic of China.

出版信息

Int J Gen Med. 2024 Nov 3;17:5039-5048. doi: 10.2147/IJGM.S475771. eCollection 2024.

DOI:10.2147/IJGM.S475771

PMID:39512258

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11542474/

Abstract

BACKGROUND

Atherosclerosis is a systemic disease that can involve multiple vascular beds. The risk factors for atherosclerosis in multiple vascular beds remain unclear. Apolipoprotein E (APOE) is involved in inflammation and lipid deposition in the process of atherosclerosis. The objective of this study was to investigate whether polymorphisms are associated with atherosclerosis in multiple vascular beds.

METHODS

A total of 416 patients with atherosclerosis in single vascular bed and 658 patients with atherosclerosis in multiple vascular beds were included. genotypes were detected and the differences of genotypes between the groups were compared. Logistic regression analysis was performed to analyze the relationship between genotypes and atherosclerosis in multiple vascular beds.

RESULTS

E3/E4 genotype frequency was lower in the patients with atherosclerosis in multiple vascular beds than that of patients with atherosclerosis in single vascular bed (11.4% vs 17.8%, =0.004). There was no significant difference in age and gender distribution, proportion of history of smoking, alcohol consumption, hypertension, and diabetes mellitus between the two groups (all >0.05), and among patients with different alleles (all >0.05). Logistic regression analysis indicated that E3/E4 genotype (E3/E4 vs E3/E3: odds ratio (OR) 0.598, 95% confidence interval (CI): 0.419-0.854, =0.005), and ε4 allele (ε4 vs ε3: OR 0.630, 95% CI: 0.444-0.895, =0.010) associated with atherosclerosis in multiple vascular beds.

CONCLUSION

ε4 allele is associated with atherosclerosis in multiple vascular beds.

摘要

背景

动脉粥样硬化是一种可累及多个血管床的全身性疾病。多个血管床发生动脉粥样硬化的危险因素仍不清楚。载脂蛋白E（APOE）参与动脉粥样硬化过程中的炎症和脂质沉积。本研究的目的是调查基因多态性是否与多个血管床的动脉粥样硬化相关。

方法

共纳入416名单一血管床动脉粥样硬化患者和658名多个血管床动脉粥样硬化患者。检测基因分型并比较两组之间基因分型的差异。进行逻辑回归分析以分析基因分型与多个血管床动脉粥样硬化之间的关系。

结果

多个血管床动脉粥样硬化患者的E3/E4基因型频率低于单一血管床动脉粥样硬化患者（11.4%对17.8%，P=0.004）。两组之间在年龄、性别分布、吸烟史、饮酒史、高血压和糖尿病比例方面无显著差异（均P>0.05），不同等位基因患者之间也无显著差异（均P>0.05）。逻辑回归分析表明，E3/E4基因型（E3/E4对E3/E3：比值比（OR）0.598，95%置信区间（CI）：0.419-0.854，P=0.005）以及ε4等位基因（ε4对ε3：OR 0.630，95%CI：0.444-0.895，P=0.010）与多个血管床的动脉粥样硬化相关。