N6-甲基腺苷（m6A）RNA 修饰在纤维化和胶原相关疾病中的作用。
N6-methyladenosine (m6A) RNA modification in fibrosis and collagen-related diseases.
机构信息
Department of Obstetrics and Gynecology, Women and Children's Hospital of Chongqing Medical University, No. 120, Longshan Road, Yubei District, Chongqing, China.
Department of Obstetrics and Gynecology, Chongqing Health Center for Women and Children, No. 120, Longshan Road, Yubei District, Chongqing, China.
出版信息
Clin Epigenetics. 2024 Sep 12;16(1):127. doi: 10.1186/s13148-024-01736-5.
Fibrosis is an abnormal tissue healing process characterized by the excessive accumulation of ECM components, such as COL I and COL III, in response to tissue injury or chronic inflammation. Recent advances in epitranscriptomics have underscored the importance of m6A modification in fibrosis. m6A, the most prevalent modification in eukaryotic RNA, is catalyzed by methyltransferases (e.g., METTL3), removed by demethylases (e.g., FTO), and recognized by reader proteins (e.g., YTHDF1/2). These modifications are crucial in regulating collagen metabolism and associated diseases. Understanding the role of m6A modification in fibrosis and other collagen-related conditions holds promise for developing targeted therapies. This review highlights the latest progress in this area.
纤维化是一种异常的组织修复过程，其特征是在组织损伤或慢性炎症的反应下，细胞外基质（ECM）成分如 COL I 和 COL III 过度积累。最近的转录后修饰组学研究进展强调了 m6A 修饰在纤维化中的重要性。m6A 是真核 RNA 中最普遍的修饰，由甲基转移酶（如 METTL3）催化，由去甲基酶（如 FTO）去除，并被阅读蛋白（如 YTHDF1/2）识别。这些修饰在调节胶原蛋白代谢和相关疾病中起着关键作用。了解 m6A 修饰在纤维化和其他与胶原蛋白相关疾病中的作用，有望为开发靶向治疗方法提供新的思路。本文综述了这一领域的最新进展。
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