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Research advances of N6-methyladenosine in diagnosis and therapy of pancreatic cancer.N6-甲基腺苷在胰腺癌诊断与治疗中的研究进展。
J Clin Lab Anal. 2022 Sep;36(9):e24611. doi: 10.1002/jcla.24611. Epub 2022 Jul 15.
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Comprehensive Analysis of N6-Methyladenosine (m6A) Writers, Erasers, and Readers in Cervical Cancer.宫颈癌中 N6-甲基腺苷（m6A）写入器、擦除器和读取器的综合分析
Int J Mol Sci. 2022 Jun 28;23(13):7165. doi: 10.3390/ijms23137165.
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N6-methyladenosine RNA modification (m6A) is of prognostic value in HPV-dependent vulvar squamous cell carcinoma.N6-甲基腺苷 RNA 修饰（m6A）对 HPV 依赖性外阴鳞状细胞癌具有预后价值。
BMC Cancer. 2022 Sep 1;22(1):943. doi: 10.1186/s12885-022-10010-x.
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Comprehensive immunohistochemical analysis of N6-methyladenosine (m6A) writers, erasers, and readers in endometrial cancer.全面免疫组织化学分析子宫内膜癌中的 N6-甲基腺苷（m6A）写入器、擦除器和读取器。
J Cancer Res Clin Oncol. 2023 Jun;149(6):2417-2424. doi: 10.1007/s00432-022-04083-1. Epub 2022 Jun 22.
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The potential role of RNA N6-methyladenosine in Cancer progression.RNA N6-甲基腺苷在癌症进展中的潜在作用。
Mol Cancer. 2020 May 12;19(1):88. doi: 10.1186/s12943-020-01204-7.
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Changes of N6-methyladenosine modulators promote breast cancer progression.N6-甲基腺苷修饰调节剂的变化促进乳腺癌的进展。
BMC Cancer. 2019 Apr 5;19(1):326. doi: 10.1186/s12885-019-5538-z.
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Epigenetic regulation of mRNA N6-methyladenosine modifications in mammalian gametogenesis.哺乳动物配子发生过程中mRNA N6-甲基腺苷修饰的表观遗传调控
Mol Hum Reprod. 2021 May 8;27(5). doi: 10.1093/molehr/gaab025.
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Role of N6-methyladenosine modification in pathogenesis of ischemic stroke.N6-甲基腺苷修饰在缺血性脑卒中发病机制中的作用。
Expert Rev Mol Diagn. 2022 Mar;22(3):295-303. doi: 10.1080/14737159.2022.2049246. Epub 2022 Mar 8.
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m6A readers, writers, erasers, and the m6A epitranscriptome in breast cancer.m6A 读码器、写码器、擦除器和乳腺癌中的 m6A 表遗传组。
J Mol Endocrinol. 2022 Dec 21;70(2). doi: 10.1530/JME-22-0110. Print 2023 Feb 1.
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Role of m6A modification in female infertility and reproductive system diseases.m6A 修饰在女性不孕不育及生殖系统疾病中的作用。
Int J Biol Sci. 2022 May 16;18(9):3592-3604. doi: 10.7150/ijbs.69771. eCollection 2022.
引用本文的文献
1
METTL3 and METTL14 drive pancreatic adenocarcinoma progression via m6A-dependent alternative splicing in PANC-1 cells.METTL3和METTL14通过PANC-1细胞中m6A依赖的可变剪接驱动胰腺腺癌进展。
Discov Oncol. 2025 Aug 21;16(1):1590. doi: 10.1007/s12672-025-03393-3.
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Role of m6A RNA methylation regulators in pancreatic cancer: interactions and potential implications.m6A RNA甲基化调节剂在胰腺癌中的作用：相互作用及潜在影响
Cancer Cell Int. 2025 Aug 4;25(1):292. doi: 10.1186/s12935-025-03922-8.
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Research progress on m6A and drug resistance in gastrointestinal tumors.胃肠道肿瘤中m6A与耐药性的研究进展
Front Pharmacol. 2025 Apr 28;16:1565738. doi: 10.3389/fphar.2025.1565738. eCollection 2025.
4
HNRNPC promotes progression of non-small cell lung cancer by maintaining TFAP2A mRNA stability.HNRNPC通过维持TFAP2A mRNA稳定性促进非小细胞肺癌进展。
Cancer Cell Int. 2025 Mar 8;25(1):85. doi: 10.1186/s12935-025-03660-x.
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The Mechanism and Latest Progress of m6A Methylation in the Progression of Pancreatic Cancer.m6A甲基化在胰腺癌进展中的机制及最新研究进展
Int J Biol Sci. 2025 Jan 13;21(3):1187-1201. doi: 10.7150/ijbs.104407. eCollection 2025.
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Emerging role of RNA modification and long noncoding RNA interaction in cancer.RNA 修饰和长非编码 RNA 相互作用在癌症中的新兴作用。
Cancer Gene Ther. 2024 Jun;31(6):816-830. doi: 10.1038/s41417-024-00734-2. Epub 2024 Feb 14.
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METTL14 drives growth and metastasis of non-small cell lung cancer by regulating pri-miR-93-5p maturation and TXNIP expression.METTL14 通过调节 pri-miR-93-5p 的成熟和 TXNIP 的表达来驱动非小细胞肺癌的生长和转移。
Genes Genomics. 2024 Feb;46(2):213-229. doi: 10.1007/s13258-023-01436-z. Epub 2023 Aug 18.
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M6A-Related Long Non-Coding RNA Displays Utility in Predicting Prognosis, Portraying the Tumor Immune Microenvironment and Guiding Immunotherapy in Pancreatic Ductal Adenocarcinoma.与m6A相关的长链非编码RNA在预测胰腺导管腺癌预后、描绘肿瘤免疫微环境及指导免疫治疗方面具有应用价值。
Vaccines (Basel). 2023 Feb 21;11(3):499. doi: 10.3390/vaccines11030499.
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N-methyladenosine (mA) reader IGF2BP1 facilitates clear-cell renal cell carcinoma aerobic glycolysis.N6-甲基腺苷(mA)读码器 IGF2BP1 促进肾透明细胞癌的有氧糖酵解。
PeerJ. 2023 Jan 18;11:e14591. doi: 10.7717/peerj.14591. eCollection 2023.
本文引用的文献
1
Circulating tumor cells in precision medicine: challenges and opportunities.循环肿瘤细胞在精准医学中的应用：挑战与机遇。
Trends Pharmacol Sci. 2022 May;43(5):378-391. doi: 10.1016/j.tips.2022.02.005. Epub 2022 Mar 7.
2
ALKBH5-mediated mA demethylation of KCNK15-AS1 inhibits pancreatic cancer progression via regulating KCNK15 and PTEN/AKT signaling.ALKBH5 介导的 mA 去甲基化调控 KCNK15-AS1 通过调节 KCNK15 和 PTEN/AKT 信号通路抑制胰腺癌进展。
Cell Death Dis. 2021 Dec 1;12(12):1121. doi: 10.1038/s41419-021-04401-4.
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RNA mA Demethylase ALKBH5 Protects Against Pancreatic Ductal Adenocarcinoma Targeting Regulators of Iron Metabolism.RNA 甲基腺嘌呤去甲基化酶 ALKBH5 通过靶向铁代谢调节因子来抵御胰腺导管腺癌。
Front Cell Dev Biol. 2021 Oct 18;9:724282. doi: 10.3389/fcell.2021.724282. eCollection 2021.
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MA-mediated up-regulation of LncRNA LIFR-AS1 enhances the progression of pancreatic cancer via miRNA-150-5p/ VEGFA/Akt signaling.MA 介导的 LncRNA LIFR-AS1 上调通过 miRNA-150-5p/VEGFA/Akt 信号通路促进胰腺癌的进展。
Cell Cycle. 2021 Dec;20(23):2507-2518. doi: 10.1080/15384101.2021.1991122. Epub 2021 Oct 17.
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mA Methylation Modification Patterns and Tumor Microenvironment Infiltration Characterization in Pancreatic Cancer.mA 甲基化修饰模式与胰腺癌肿瘤微环境浸润特征。
Front Immunol. 2021 Sep 20;12:739768. doi: 10.3389/fimmu.2021.739768. eCollection 2021.
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Characterization of Modification Patterns, Biological Function, Clinical Implication, and Immune Microenvironment Association of mA Regulators in Pancreatic Cancer.胰腺癌中 mA 调控因子的修饰模式、生物学功能、临床意义及免疫微环境关联的特征分析
Front Genet. 2021 Sep 17;12:702072. doi: 10.3389/fgene.2021.702072. eCollection 2021.
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m6A demethylase FTO suppresses pancreatic cancer tumorigenesis by demethylating and inhibiting Wnt signaling.m6A去甲基化酶FTO通过去甲基化和抑制Wnt信号通路来抑制胰腺癌的肿瘤发生。
Mol Ther Nucleic Acids. 2021 Jun 24;25:277-292. doi: 10.1016/j.omtn.2021.06.005. eCollection 2021 Sep 3.
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mA Methyltransferase METTL14-Mediated Upregulation of Cytidine Deaminase Promoting Gemcitabine Resistance in Pancreatic Cancer.甲硫腺苷甲基转移酶METTL14介导的胞苷脱氨酶上调促进胰腺癌吉西他滨耐药
Front Oncol. 2021 Aug 11;11:696371. doi: 10.3389/fonc.2021.696371. eCollection 2021.
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Diagnostic value of IMP3 and p53 immunohistochemical staining in EUS-guided fine-needle aspiration for solid pancreatic tumors.EUS-引导下细针穿刺活检中 IMP3 和 p53 免疫组化染色对胰腺实性肿瘤的诊断价值。
Sci Rep. 2021 Aug 26;11(1):17257. doi: 10.1038/s41598-021-96492-4.
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-methyladenosine-Mediated Upregulation of WTAPP1 Promotes WTAP Translation and Wnt Signaling to Facilitate Pancreatic Cancer Progression.m6A 介导的 WTAPP1 上调促进 WTAP 翻译和 Wnt 信号传导，从而促进胰腺癌进展。
Cancer Res. 2021 Oct 15;81(20):5268-5283. doi: 10.1158/0008-5472.CAN-21-0494. Epub 2021 Aug 6.
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