Knight G, Jennings A M, Boulton A J, Tomlinson S, Ward J D
Br Med J (Clin Res Ed). 1985 Aug 10;291(6492):371-2. doi: 10.1136/bmj.291.6492.371.
During a feasibility study of the use of insulin pumps to treat diabetes ketoacidosis occurred at a rate of 0.14 episodes/patient/year in the first year but was lower in subsequent years. A case of cardiac arrest secondary to hyperkalaemia during ketoacidosis occurred in a patient treated with a pump. The mean (SD) serum potassium concentration on presentation to hospital with ketoacidosis was significantly higher in patients treated with a pump (5.7 (1.1) mmol(mEq)/l) than those treated with conventional injections of insulin (4.9(0.9) mmol/l; p less than 0.01). The high rate of ketoacidosis and raised serum potassium concentrations during treatment with the pump creates doubt about the use of this treatment as an alternative regimen for large numbers of patients in a busy diabetic clinic.
在一项关于使用胰岛素泵治疗糖尿病酮症酸中毒的可行性研究中，第一年的发生率为0.14次发作/患者/年，但在随后几年中较低。一名使用胰岛素泵治疗的患者在酮症酸中毒期间发生了继发于高钾血症的心脏骤停。发生酮症酸中毒时入院的患者中，使用胰岛素泵治疗的患者血清钾浓度均值（标准差）（5.7（1.1）mmol（mEq）/L）显著高于接受常规胰岛素注射治疗的患者（4.9（0.9）mmol/L；p<0.01）。胰岛素泵治疗期间酮症酸中毒的高发生率和血清钾浓度升高，让人怀疑这种治疗方法能否作为繁忙糖尿病诊所中大量患者的替代治疗方案。
