Stephen Norton, Jeyaraman Rajashree, Srinivas Bheemanathi Hanuman, Dileep Jude, Nagendran Prabhakaran, Manivannan Prabhu
Department of Pathology, Jawaharlal Institute of Post Graduate Medical Education and Research Karaikal, India.
Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research Puducherry, India.
Int J Clin Exp Pathol. 2024 Aug 15;17(8):252-256. doi: 10.62347/ACDG7634. eCollection 2024.
Leukemia cutis (LC) is defined as infiltration of the skin by leukemic cells resulting in clinically recognizable cutaneous lesions. The lesions range from violaceous papules, plaques, nodules, blisters, maculopapular rash and as erythroderma. LC can precede or happen after the presentation of leukemia. Here, we report a case of Mixed phenotype Acute leukemia (MPAL) presenting as LC (erythematous & violaceous nodules) which is a rare as well as a grave combination as it carries a worse prognosis. Here, we present a case of MPAL which presented as Leukemia Cutis proven on biopsy. The paper discusses the importance of identifying LC both in a clinical and a pathological pretext as it is important to start the Chemotherapy for MPAL at the earliest for a better outcome.
皮肤白血病（LC）定义为白血病细胞浸润皮肤，导致临床上可识别的皮肤病变。病变范围从紫红色丘疹、斑块、结节、水疱、斑丘疹皮疹到红皮病。LC可先于白血病出现或在白血病出现后发生。在此，我们报告一例以LC（红斑及紫红色结节）为表现的混合表型急性白血病（MPAL），这是一种罕见且严重的组合，因其预后较差。在此，我们呈现一例经活检证实为皮肤白血病表现的MPAL病例。本文讨论了在临床和病理背景下识别LC的重要性，因为尽早开始MPAL的化疗对于获得更好的结果很重要。
