Du Amy X, Hung Tawny, Surmanowicz Philip, Gniadecki Robert
Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, Canada.
Department of Laboratory Medicine and Pathology, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, Canada.
SAGE Open Med Case Rep. 2020 May 6;8:2050313X20919638. doi: 10.1177/2050313X20919638. eCollection 2020.
Aleukemic leukemia cutis is a rare condition in which malignant white cells invade the skin before they appear in the peripheral blood or bone marrow. It is often associated with a poor prognosis. The condition presents a diagnostic challenge as its manifestations are quite variable terms of lesion type. It can manifest as papules, nodules, and/or plaques, and in rare cases erythematous macules, blisters, and ulcers. The most commonly affected areas of the body are the lower extremities, followed by the upper extremities, back, trunk, and face. Due to the non-specific presentation of the disease, skin biopsy and comprehensive immunohistochemical testing can be extremely helpful in the diagnostic work-up. We describe a case of leukemia cutis presenting prior to acute myelogenous leukemia that was initially misdiagnosed as hyper-IgG4 disease.
白细胞不增多性白血病性皮肤浸润是一种罕见疾病，其中恶性白细胞在外周血或骨髓中出现之前就侵入皮肤。它通常与预后不良相关。由于其病变类型的表现变化很大，该疾病在诊断上具有挑战性。它可表现为丘疹、结节和/或斑块，罕见情况下可表现为红斑、水疱和溃疡。身体最常受累的部位是下肢，其次是上肢、背部、躯干和面部。由于该疾病表现不具特异性，皮肤活检和全面的免疫组化检测在诊断检查中可能非常有帮助。我们描述了一例急性髓系白血病之前出现的白血病性皮肤浸润病例，该病例最初被误诊为IgG4相关性疾病。
