Dutt Aditya, Arcinas Lauren, Chen Justin, Shaikh Rahila, Jun Sejoon, Kooner Amritpal, Gandhi Dhruv, Dolehide Conor
Dermatology, Midwestern University Chicago College of Osteopathic Medicine, Downers Grove, USA.
Dermatology, University of Ottawa, Ottawa, CAN.
Cureus. 2024 Aug 11;16(8):e66653. doi: 10.7759/cureus.66653. eCollection 2024 Aug.
Systemic sclerosis (SSc) is a complex, autoimmune connective tissue disease that affects multiple organs in the body, culminating in a variance of severity and a reduced quality of life. Breast cancer (BC) also affects patients with SSc, and these two conditions affect a similar demographic. With this systematic review, we aim to characterize the links between SSc and BC. Characterizing possible links between SSc and breast malignancies is important for advancing the understanding of SSc management and comorbidities. In this systematic meta-analysis, a comprehensive literature search was conducted in PubMed using relevant keywords and MeSH terms. The inclusion criteria included an English-language retrospective analysis that characterized patients with SSc with or without BC. Two independent reviewers assessed the study's eligibility based on predetermined criteria. Data extraction included patient antibody measurements, demographics (age and gender), family history, social behaviors (alcohol use and smoking history), concurrent condition treatments, and adverse effects following treatment. Thirteen articles were identified in the literature with relevant data on SSc and BC patients. Studies encompassed research about SSc patients with or without BC and relevant risk factors being measured. SSc was found to have a link to antibodies widely associated with cancer. Adverse treatment outcomes and concurrent conditions of BC were found when patients had a family history of SSc, BC, or an alcohol or smoking history. Our results suggest that the presence of antinuclear antibodies, anti-centromere antibodies, or anti-topoisomerase antibodies in SSc patients is correlated with BC. Out of the three antibodies, ATA seemed to be found more commonly in patients with SSc and malignancy across the studies. This systematic review discusses the link between SSc and BC through patients with relevant clinical markers, medical histories, and treatments. However, further research is necessary to advance the linkage between SSc and BC and determine whether management of one condition may prevent or alleviate the other.
系统性硬化症（SSc）是一种复杂的自身免疫性结缔组织疾病，会影响身体多个器官，最终导致严重程度各异且生活质量下降。乳腺癌（BC）也会影响SSc患者，这两种疾病影响的人群相似。通过本系统评价，我们旨在描述SSc与BC之间的联系。明确SSc与乳腺恶性肿瘤之间的可能联系对于增进对SSc管理及合并症的理解很重要。在本系统荟萃分析中，我们使用相关关键词和医学主题词在PubMed中进行了全面的文献检索。纳入标准包括对有或无BC的SSc患者进行特征描述的英文回顾性分析。两名独立评审员根据预定标准评估研究的 eligibility。数据提取包括患者抗体测量、人口统计学特征（年龄和性别）、家族史、社会行为（饮酒和吸烟史）、并发疾病治疗情况以及治疗后的不良反应。在文献中识别出13篇有关SSc和BC患者的相关数据的文章。研究涵盖了对有或无BC的SSc患者以及所测量的相关危险因素的研究。发现SSc与广泛与癌症相关的抗体存在联系。当患者有SSc、BC家族史或饮酒或吸烟史时，会出现BC的不良治疗结果和并发情况。我们的结果表明，SSc患者中抗核抗体、抗着丝点抗体或抗拓扑异构酶抗体的存在与BC相关。在这三种抗体中，ATA在各项研究中似乎在患有SSc和恶性肿瘤的患者中更常见。本系统评价通过具有相关临床标志物、病史和治疗方法
