Dekker Nitert Marloes, Ovadia Caroline
School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia.
Department of Women and Children's Health, King's College London, London, UK.
Obstet Med. 2024 Sep;17(3):168-174. doi: 10.1177/1753495X241258383. Epub 2024 Jun 5.
Bile acid metabolism is partially regulated through the activity of the gut microbiota. Primary bile acids can be deconjugated and modified by bacteria expressing bile salt hydrolase and other enzymes, changing bile acid recycling by changing the interactions between enterocytes and hepatocytes. The modified bile acids can also activate signalling in cells regulating metabolism including colonic L-cells, skeletal muscle cells and brown adipocytes. In pregnancy, both bile acid metabolism and gut microbiota composition are altered. In women with intrahepatic cholestasis of pregnancy, the changes in bile acid metabolism are exacerbated and there is some evidence that the gut microbiota composition is also altered. Here we review the crosstalk between the liver and the gut especially in women with intrahepatic cholestasis of pregnancy, with a focus on the role of the gut microbiota in this crosstalk.
胆汁酸代谢部分受肠道微生物群活性调节。初级胆汁酸可被表达胆盐水解酶和其他酶的细菌去结合和修饰，通过改变肠上皮细胞与肝细胞之间的相互作用来改变胆汁酸循环。修饰后的胆汁酸还可激活调节代谢的细胞中的信号传导，包括结肠L细胞、骨骼肌细胞和棕色脂肪细胞。在怀孕期间，胆汁酸代谢和肠道微生物群组成都会发生改变。在患有妊娠期肝内胆汁淤积症的女性中，胆汁酸代谢的变化会加剧，并且有一些证据表明肠道微生物群组成也会改变。在此，我们综述肝脏与肠道之间的相互作用，尤其是在患有妊娠期肝内胆汁淤积症的女性中，重点关注肠道微生物群在这种相互作用中的作用。
