Rabby Md Golam, Suzauddula Md, Hasan Md Sakib, Dewan Mahbubur Alam, Islam Md Numan
Department of Nutrition and Food Technology, Jashore University of Science and Technology, Jashore, 7408, Bangladesh.
College of Agriculture and Natural Resources, National Chung Hsing University, Taichung City, 40227, Taiwan.
Heliyon. 2024 Aug 21;10(16):e36546. doi: 10.1016/j.heliyon.2024.e36546. eCollection 2024 Aug 30.
Type 2 diabetes (T2D) and hypertension are global public health concerns and major metabolic disorders in humans. Experimental evidence indicates considerable hereditary influences on the etiology of T2D and hypertension, but the molecular basis of these diseases is still limited. Thus, the current study analyzed 185 (132 T2D and 53 hypertension) GWAS catalog datasets and identified 83 common genes linked to T2D and hypertension pathogenesis. These genes were further examined using various bioinformatics approaches to elucidate their molecular mechanisms underlying the pathophysiology of T2D and hypertension. Gene ontology (GO) analysis revealed the biological, cellular, and molecular functions of these genes, which were also linked to different T2D and hypertension pathways. Specifically, seven genes were found to be crucial for T2D, and nine were directly associated with hypertension. Protein-protein interaction (PPI) analysis identified 28 candidate genes and seven hub genes through 11 topological methods. Among 231 miRNAs, seven were significant in interacting with the hub genes, and nine transcription factors (TFs) out of 36 were linked to these hub genes. Additionally, two of the seven hub genes were downregulated by 43 FDA-approved drugs. These findings elucidate the molecular processes underlying T2D and hypertension, suggesting that targeting these genes could lead to future drug development and therapeutic strategies to treat T2D and hypertension.
2型糖尿病（T2D）和高血压是全球公共卫生关注的问题，也是人类主要的代谢紊乱疾病。实验证据表明，遗传因素对T2D和高血压的病因有相当大的影响，但这些疾病的分子基础仍然有限。因此，本研究分析了185个（132个T2D和53个高血压）全基因组关联研究（GWAS）目录数据集，确定了83个与T2D和高血压发病机制相关的常见基因。使用各种生物信息学方法对这些基因进行了进一步研究，以阐明它们在T2D和高血压病理生理学中的分子机制。基因本体（GO）分析揭示了这些基因的生物学、细胞和分子功能，它们也与不同的T2D和高血压途径相关。具体而言，发现七个基因对T2D至关重要，九个基因与高血压直接相关。蛋白质-蛋白质相互作用（PPI）分析通过11种拓扑方法确定了28个候选基因和七个枢纽基因。在231个微小RNA（miRNA）中，有七个在与枢纽基因相互作用方面具有显著性，在36个转录因子（TF）中有九个与这些枢纽基因相关。此外，七个枢纽基因中的两个被43种美国食品药品监督管理局（FDA）批准的药物下调。这些发现阐明了T2D和高血压的分子过程，表明针对这些基因可能会带来未来治疗T2D和高血压的药物开发和治疗策略。
