Welsch C W
Cancer Res. 1985 Aug;45(8):3415-43.
The carcinogen-induced rat mammary carcinoma model, developed a quarter of a century ago by Dr. Charles Brenton Huggins, is today the standard laboratory animal model in the study of human breast cancer. This model has a number of features that make it particularly attractive to the experimental oncologist, e.g., tumor induction ease and reliability, organ site specificity, tumors of ductal origin, tumors of predominantly carcinomatous histopathological characteristics, tumors of varying growth factor and/or hormone responsiveness, and the potential to examine tumor initiation and promotion processes. Since the development of this model, an extensive literature describing the biological behavior and responsiveness of these tumors has been provided. The purpose of this communication is to condense, summarize, and integrate this vast literature into a single review with the intent on facilitating information acquisition and conceptualism by both the new and the established experimental oncologist. In addition, and equally important, this communication is a tribute to Dr. Huggins, whose pioneering efforts in the development of this model and whose scientific contributions and dedication to the oncological sciences in general have made an important and lasting impact on us all.
25年前由查尔斯·布伦顿·哈金斯博士建立的致癌物诱导大鼠乳腺癌模型，如今是研究人类乳腺癌的标准实验动物模型。该模型具有许多特点，使其对实验肿瘤学家特别有吸引力，例如，肿瘤诱导容易且可靠、器官部位特异性、导管起源的肿瘤、主要具有癌组织病理学特征的肿瘤、具有不同生长因子和/或激素反应性的肿瘤，以及研究肿瘤起始和促进过程的潜力。自该模型建立以来，已经有大量文献描述了这些肿瘤的生物学行为和反应性。本通讯的目的是将这些大量文献进行浓缩、总结并整合为一篇综述，旨在方便新老实验肿瘤学家获取信息和形成概念。此外，同样重要的是，本通讯是对哈金斯博士的致敬，他在该模型开发中的开创性努力以及他对肿瘤学科学的总体科学贡献和奉献精神，对我们所有人都产生了重要且持久的影响。
